The evaluation of both the expression and serum protein levels of Caspase-3 gene in patients with different degrees of SARS-CoV2 infection

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dc.authoridYildiz Gulhan, Pinar/0000-0002-5347-2365
dc.contributor.authorGulhan, Pinar Yildiz
dc.contributor.authorEroz, Recep
dc.contributor.authorAtaoglu, Ozlem
dc.contributor.authorInce, Nevin
dc.contributor.authorDavran, Fatih
dc.contributor.authorOzturk, Cihadiye Elif
dc.contributor.authorBalbay, Oner Abidin
dc.date.accessioned2021-12-01T18:47:51Z
dc.date.available2021-12-01T18:47:51Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractTo evaluate the effects of Caspase-3 (CASP3) gene expression and serum levels on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A total of 41 individuals (male: 21; female: 20) with SARS-CoV-2 infection were included in the current study. Hemograms were examined from patient blood samples, and CASP3 gene expression levels were detected. Also, human CASP3 levels were determined from the serum samples of patients. The mean age of patients was 56.220 +/- 18.937 years. Significant differences were detected among all groups for CASP3 2-Delta Delta Ct (p = 0.014) and CASP3 concentration (p = 0.024). The relationship between CASP3 2-Delta Delta Ct levels and hemoglobin (p = 0.023), between CASP3 2-Delta Delta Ct levels and C-reactive protein (CRP) (p = 0.001), between CASP3 2-Delta Delta Ct levels and ferritin (p = 0.003), between CASP3 2-Delta Delta Ctlevels and lactate dehydrogenase (p = 0.001), and between CASP3 2-Delta Delta Ct levels and SpO(2) (p = 0.006) were statistically significant. Also, the relationship between CASP3 concentration levels and SpO(2) was statistically significant (p < 0.046). The CASP3 gene and/or its products have an important function to prevent injury caused by SARS-CoV-2 infection. They play crucial roles in maintaining cellular homeostasis and viability. Perhaps CASP3 levels may provide information about the severity of the disease.en_US
dc.description.sponsorshipDuzce UniversityDuzce Universityen_US
dc.description.sponsorshipDuzce University coordinators of scientific research projectsen_US
dc.identifier.doi10.1002/jmv.27362
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.pmid34585746en_US
dc.identifier.scopus2-s2.0-85117183718en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.27362
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10391
dc.identifier.wosWOS:000708295100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCASP3 geneen_US
dc.subjectcellular homeostasisen_US
dc.subjectSARS-CoV-2en_US
dc.subjectClinical Characteristicsen_US
dc.subjectCoronavirus Diseaseen_US
dc.subjectD-Dimeren_US
dc.subjectCovid-19en_US
dc.subjectMortalityen_US
dc.subjectCellsen_US
dc.titleThe evaluation of both the expression and serum protein levels of Caspase-3 gene in patients with different degrees of SARS-CoV2 infectionen_US
dc.typeArticleen_US

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