Adjuvant chemotherapy outcomes in patients over 65 years with early stage colorectal carcinoma

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dc.contributor.authorCivelek, Burak
dc.contributor.authorAksoy, Sercan
dc.contributor.authorŞendur, Mehmet Ali Nahit
dc.contributor.authorYazıcı, Ozan
dc.contributor.authorKanmaz, Hüseyin
dc.contributor.authorKöş, Fahriye Tuğba
dc.contributor.authorZengin, Nurullah
dc.date.accessioned2020-04-30T22:39:00Z
dc.date.available2020-04-30T22:39:00Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAksoy, Sercan/0000-0003-4984-1049en_US
dc.descriptionWOS: 000347742000008en_US
dc.descriptionPubMed: 25536594en_US
dc.description.abstractPurpose: To evaluate the clinicopathological characteristics and the outcomes of adjuvant chemotherapy of patients with colorectal cancer aged >= 65 years. Methods: Between March 2003 and December 2010, the medical files of 562.colorectal cancer patients >= 65 years of age who were under follow-up in Ankara Numune Educational Hospital, Department of Medical Oncology, were retrospectively analyzed. Only 210 patients with non-metastatic disease at the time of diagnosis and those who had undergone surgical resection were included in the study. Results: The patient median age was 71 years (range 65-87). Of the patients, 115 (54.8%) were males and 95 (45.2%) females. The most common involvement site was the rectum (41.4%), followed by sigmoid colon (21.9%). According to the TNM staging, 12.4% patients had stage I, 48.6% stage II, and 39% stage III disease. At the time of diagnosis 19 patients (9%) had ECOG PS 0, 112 (53.3%) ECOG PS 1, 61(29%) ECOG PS 2, and 16 (7.7%) ECOG PS 3. Of the patients, 141 (66.5%) were administered adjuvant chemotherapy, whereas 69 patients (33%) were not. Thirty nine (18.6%) patients with adjuvant chemotherapy received fluorouracil/folinic acid (PUPA) weekly, 59 (28%) received FUFA infusion, and 43 (21%) received oxaliplatin, folinic acid and 5-fluorouracil (FOLFOX-4) regimen. The median follow-up was 27 months (range 1-116). Disease free survival (DFS) was not reached during the follow-up period. The estimated overall survival (OS) was 68.8 months (range 48.5-73.0). Sixty six (31%) patients died during follow-up. Conclusion: Elderly patients with high risk for recurrence of colorectal cancer must receive adjuvant chemotherapy after curative surgery. Infusional PUPA seems more effective than other regimens.en_US
dc.identifier.endpage912en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage906en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2559
dc.identifier.volume19en_US
dc.identifier.wosWOS:000347742000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal Of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadjuvant chemotherapyen_US
dc.subjectcolorectal canceren_US
dc.subjectelderly patientsen_US
dc.subjectFOLFOX-4en_US
dc.subjectFUFAen_US
dc.titleAdjuvant chemotherapy outcomes in patients over 65 years with early stage colorectal carcinomaen_US
dc.typeArticleen_US

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