Managing atypical and typical herpetic central nervous system infections: results of a multinational study

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dc.contributor.authorÇağ, Yasemin
dc.contributor.authorErdem, Hakan
dc.contributor.authorLeib, Stephen
dc.contributor.authorDefres, Sylviane
dc.contributor.authorKaya, Selçuk
dc.contributor.authorLarsen, Lykke
dc.contributor.authorElaldı, Nazif
dc.date.accessioned2020-04-30T23:19:04Z
dc.date.available2020-04-30T23:19:04Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionGhaydaa, Shehata/0000-0002-3631-893X; Senbayrak, Seniha/0000-0002-4983-6613; Leib, Stephen/0000-0002-1106-6123; Beraud, Guillaume/0000-0002-4705-0916; Leib, Stephen L/0000-0002-1106-6123; Gunst, Jesper/0000-0002-3787-0259; johansen, isik somuncu/0000-0002-2189-9823; Larsen, Lykke/0000-0002-4113-4182; Stahl, Jean Paul/0000-0002-0086-3557; Karabay, Oguz/0000-0003-0502-432X; VAHABOGLU, Haluk/0000-0001-8217-1767; Kanj, Souha/0000-0001-6413-3396en_US
dc.descriptionWOS: 000379252100027en_US
dc.descriptionPubMed: 27085724en_US
dc.description.abstractThere have been many studies pertaining to the management of herpetic meningoencephalitis (HME), but the majority of them have focussed on virologically unconfirmed cases or included only small sample sizes. We have conducted a multicentre study aimed at providing management strategies for HME. Overall, 501 adult patients with PCR-proven HME were included retrospectively from 35 referral centres in 10 countries; 496 patients were found to be eligible for the analysis. Cerebrospinal fluid (CSF) analysis using a PCR assay yielded herpes simplex virus (HSV)-1 DNA in 351 patients (70.8%), HSV-2 DNA in 83 patients (16.7%) and undefined HSV DNA type in 62 patients (12.5%). A total of 379 patients (76.4%) had at least one of the specified characteristics of encephalitis, and we placed these patients into the encephalitis presentation group. The remaining 117 patients (23.6%) had none of these findings, and these patients were placed in the nonencephalitis presentation group. Abnormalities suggestive of encephalitis were detected in magnetic resonance imaging (MRI) in 83.9% of the patients and in electroencephalography (EEG) in 91.0% of patients in the encephalitis presentation group. In the nonencephalitis presentation group, MRI and EEG data were suggestive of encephalitis in 33.3 and 61.9% of patients, respectively. However, the concomitant use of MRI and EEG indicated encephalitis in 96.3 and 87.5% of the cases with and without encephalitic clinical presentation, respectively. Considering the subtle nature of HME, CSF HSV PCR, EEG and MRI data should be collected for all patients with a central nervous system infection. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.cmi.2016.03.027en_US
dc.identifier.issn1198-743X
dc.identifier.issn1469-0691
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.cmi.2016.03.027
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3636
dc.identifier.volume22en_US
dc.identifier.wosWOS:000379252100027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofClinical Microbiology And Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtypical presentationen_US
dc.subjectencephalitisen_US
dc.subjectherpes simplex virusen_US
dc.subjectmanagingen_US
dc.subjectmeningitisen_US
dc.titleManaging atypical and typical herpetic central nervous system infections: results of a multinational studyen_US
dc.typeArticleen_US

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