Lifestyle and Metabolic Determinants of Incident Hypertension, With Special Reference to Cigarette Smoking: A Longitudinal Population-Based Study

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dc.contributor.authorOnat, Altan
dc.contributor.authorUğur, Murat
dc.contributor.authorHergenç, Gülay
dc.contributor.authorCan, Günay
dc.contributor.authorOrdu, Serkan
dc.contributor.authorDursunoğlu, Dursun
dc.date.accessioned2020-04-30T23:18:55Z
dc.date.available2020-04-30T23:18:55Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000262537300009en_US
dc.descriptionPubMed: 19039311en_US
dc.description.abstractBACKGROUND Lifestyle and metabolic determinants of incident hypertension in a population with a high prevalence of metabolic syndrome (MetS) need to be further assessed. METHODS A representative sample of middle-aged and elderly Turkish adults was prospectively evaluated over a mean 7.4 years, after exclusion of prevalent hypertension and major renal dysfunction. RESULTS In 2,427 men and women, aged 45.8 +/- 11.7 years, Kaplan-Meier analysis showed in combined genders mean time to incident hypertension to be 7.23 years in never, 7.78 years in current smokers (P < 0.001). Age and female sex were major determinants of subsequent hypertension after adjustment for physical activity grade, family income bracket, smoking status, usage of alcohol and of hormone replacement or birth control pill. Relative risk (RR) for incident hypertension of current vs. never smoking was reduced in women (P = 0.058) and both genders combined (P = 0.054). Former smokers uniformly exhibited significantly higher risk for the development of hypertension than both never (P = 0.054) and current (P < 0.001) smokers, whereby abdominally obese individuals were at increased risk. In further multivariable models, circulating C-reactive protein (CRP) and fasting insulin emerged as modest independent determinants and waist girth, modulated by current smoking, as a major determinant of subsequent hypertension. CONCLUSIONS Age, female sex, and waist circumference are major and serum insulin and CRP modest determinants of incident hypertension in middle-aged Turkish adults in whom current cigarette smoking plays a protective role at borderline significance, largely by modulating waist girth. Former smokers with abdominal obesity are under higher risk of subsequent hypertension than current smokers.en_US
dc.description.sponsorshipTurkish Adult Risk Factoren_US
dc.description.sponsorshipWe thank the Turkish Society of Cardiology and the various pharmaceutical and nutritional companies (AstraZeneca, Novartis, Pfizer, SanofiAventis, Istanbul) that have supported financially the Turkish Adult Risk Factor surveys over the years. We appreciate the dedicated works of Z. Kucukdurmaz, S. Bulur, Z. Kaya, and M. Ozmay, the co-workers in the survey teams.en_US
dc.identifier.doi10.1038/ajh.2008.332en_US
dc.identifier.endpage162en_US
dc.identifier.issn0895-7061
dc.identifier.issn1941-7225
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage156en_US
dc.identifier.urihttps://doi.org/10.1038/ajh.2008.332
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3581
dc.identifier.volume22en_US
dc.identifier.wosWOS:000262537300009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofAmerican Journal Of Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleLifestyle and Metabolic Determinants of Incident Hypertension, With Special Reference to Cigarette Smoking: A Longitudinal Population-Based Studyen_US
dc.typeArticleen_US

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