Evaluation of the Early Effects of Childhood Asthma and Its Treatment on Cardiac Function as Revealed by Two-Dimensional Speckle-Tracking Echocardiography

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dc.authorwosidCoşkun, Gökhan/HJY-0584-2023
dc.contributor.authorÖzde, Şükriye
dc.contributor.authorKayapınar, Osman
dc.contributor.authorDoğru, Mahmut
dc.contributor.authorAktüre, Gülşah
dc.contributor.authorKaya, Adnan
dc.contributor.authorCoşkun, Gökhan
dc.contributor.authorKeskin, Muhammed
dc.date.accessioned2023-07-26T11:50:47Z
dc.date.available2023-07-26T11:50:47Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.description.abstractThere is minimal information available regarding the early effects of bronchial asthma (BA) and its treatment on cardiac function in children. We used two-dimensional speckle-tracking echocardiography (2D-STE) to evaluate cardiac function before and after the treatment of childhood BA. We enrolled 44 children with moderate and severe BA who had not been treated over the preceding 3 months or who were newly diagnosed. All children received the same treatment (that recommended by the Global Initiative for Asthma [GINA] in 2017). All children also underwent transthoracic 2D-STE before treatment and 6 months later. Clinical data were compared before and after treatment. After treatment, significant increases were evident in right ventricular (RV) systolic and diastolic strain, as well as the systolic strain rate. Before and after treatment, the RV global longitudinal systolic strains were - 22.8 +/- 3.6 and - 25.1 +/- 4.5, respectively (p = 0.036); the RV global longitudinal diastolic strains were - 18.5 +/- 6.0 and - 21.5 +/- 5.2, respectively (p = 0.038); and the RV systolic strain rates were - 1.26 +/- 0.4 and - 1.12 +/- 0.3, respectively (p = 0.025). After treatment, significant increases were observed in the right atrial (RA) peak longitudinal strain and strain rate. Before and after treatment, the RA peak atrial longitudinal strains were 32.5 +/- 10.8 and 44.7 +/- 11.2, respectively (p = 0.042) and the RA longitudinal strain rates were - 1.6 +/- 0.3 and - 2.0 +/- 0.5, respectively (p = 0.041). RV and RA subclinical dysfunction may develop in children with early-stage BA. However, asthma treatment appears to improve such dysfunction. In children with BA, clinical and subclinical changes in cardiac functions can be easily detected via 2D-STE.en_US
dc.identifier.doi10.1007/s00246-022-02941-w
dc.identifier.issn0172-0643
dc.identifier.issn1432-1971
dc.identifier.pmid36038783en_US
dc.identifier.scopus2-s2.0-85137241859en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00246-022-02941-w
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12430
dc.identifier.wosWOS:000847277300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖzde, Şükriye
dc.institutionauthorKayapınar, Osman
dc.institutionauthorDoğru, Mahmut
dc.institutionauthorAktüre, Gülşah
dc.institutionauthorKaya, Adnan
dc.institutionauthorCoşkun, Gökhan
dc.institutionauthorKeskin, Muhammed
dc.institutionauthorÖzde, Cem
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectChildhood Asthma; Right Ventricle; Longitudinal Strain; Atrial Strainen_US
dc.subjectAmerican-Society; Myocardial-Infarction; European Association; Bronchial-Asthma; Doppler; Children; Heart; Recommendations; Quantification; Managementen_US
dc.titleEvaluation of the Early Effects of Childhood Asthma and Its Treatment on Cardiac Function as Revealed by Two-Dimensional Speckle-Tracking Echocardiographyen_US
dc.typeArticleen_US

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