May Argyrophilic Nucleolar Organizer Regions be the New Marker of a Hypoxic Response in Non ST Elevation Myocardial Infarction?

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dc.authorwosidEr, Recep/HFZ-9751-2022
dc.contributor.authorDamar, Ibrahim Halil
dc.contributor.authorEroz, Recep
dc.date.accessioned2023-04-10T20:31:01Z
dc.date.available2023-04-10T20:31:01Z
dc.date.issued2022
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractObjective: Non-ST elevation myocardial infarction (NSTEMI) is a type of acute coronary syndrome and its' incidence is similarly high to ST-elevation myocardial infarction. Nucleolar organizing regions (NORs) are located of the secondary structure of acrocentric chromosome and composed of proteins and ribosomal DNA (rDNA) some of which are argyrophilic. We aimed to investigate the change of AgNOR proteins, which increase in hypoxia, in patients with NSTEMI. Methods: A total of 125 participants, 63 patients with NSTEMI and 62 volunteers without any acute coronary syndrome were included in the study. Echocardiography was performed and both mean AgNOR Number and total AgNOR area/total nuclear area (TAA/TNA) were detected for each individuals. Results: The mean AgNOR number and TAA/TNA ratio were significantly higher in the NSTEMI group than control (p<0.001). Also, statistically significant relations between TAA/TNA and all of creatinine, hemoglobin, WBC(mu l/ml), monocyte, neutrophil, neutrophil /lymphocyte ratio, monocyte/lymphocyte ratio were detected (p<0.05 for all). Also, statistically significant relations between mean AgNOR number and all of fasting blood sugar, HDL, WBC(mu l/ml), monocyte, neutrophil, EF were detected (p<0.001). Conclusions: Both AgNOR protein amounts may be used as a marker for NSTEMI. It may also contribute to the prediction of the outcomes by providing some prognostic information in NSTEMI.en_US
dc.identifier.doi10.18521/ktd.1073568
dc.identifier.endpage141en_US
dc.identifier.issn1309-3878
dc.identifier.issue1en_US
dc.identifier.startpage132en_US
dc.identifier.trdizinid511251en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.1073568
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/511251
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12023
dc.identifier.volume14en_US
dc.identifier.wosWOS:000821639100018en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tıp Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgnor; Hypoxia; Nor; Nstemien_US
dc.subjectProtein-Synthesis; Lymphocyte Ratio; Prognostic Value; Neutrophil; Cellsen_US
dc.titleMay Argyrophilic Nucleolar Organizer Regions be the New Marker of a Hypoxic Response in Non ST Elevation Myocardial Infarction?en_US
dc.typeArticleen_US

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