May Argyrophilic Nucleolar Organizer Regions be the New Marker of a Hypoxic Response in Non ST Elevation Myocardial Infarction?
Yükleniyor...
Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Duzce Univ, Fac Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Non-ST elevation myocardial infarction (NSTEMI) is a type of acute coronary syndrome and its' incidence is similarly high to ST-elevation myocardial infarction. Nucleolar organizing regions (NORs) are located of the secondary structure of acrocentric chromosome and composed of proteins and ribosomal DNA (rDNA) some of which are argyrophilic. We aimed to investigate the change of AgNOR proteins, which increase in hypoxia, in patients with NSTEMI. Methods: A total of 125 participants, 63 patients with NSTEMI and 62 volunteers without any acute coronary syndrome were included in the study. Echocardiography was performed and both mean AgNOR Number and total AgNOR area/total nuclear area (TAA/TNA) were detected for each individuals. Results: The mean AgNOR number and TAA/TNA ratio were significantly higher in the NSTEMI group than control (p<0.001). Also, statistically significant relations between TAA/TNA and all of creatinine, hemoglobin, WBC(mu l/ml), monocyte, neutrophil, neutrophil /lymphocyte ratio, monocyte/lymphocyte ratio were detected (p<0.05 for all). Also, statistically significant relations between mean AgNOR number and all of fasting blood sugar, HDL, WBC(mu l/ml), monocyte, neutrophil, EF were detected (p<0.001). Conclusions: Both AgNOR protein amounts may be used as a marker for NSTEMI. It may also contribute to the prediction of the outcomes by providing some prognostic information in NSTEMI.
Açıklama
Anahtar Kelimeler
Agnor; Hypoxia; Nor; Nstemi, Protein-Synthesis; Lymphocyte Ratio; Prognostic Value; Neutrophil; Cells
Kaynak
Konuralp Tip Dergisi
WoS Q DeÄŸeri
Scopus Q DeÄŸeri
Cilt
14
Sayı
1
