Some Positive Effects of Pine Oil on Brain Tissue in Streptozotocin-Induced Diabetic Rats

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dc.contributor.authorDemir, Ersin
dc.contributor.authorKeser, Serhat
dc.contributor.authorYılmaz, Ökkeş
dc.date.accessioned2020-04-30T23:32:07Z
dc.date.available2020-04-30T23:32:07Z
dc.date.issued2016
dc.departmentDÜ, Ziraat Fakültesi, Tarımsal Biyoteknoloji Bölümüen_US
dc.descriptionKeser, Serhat/0000-0002-9678-1053;en_US
dc.descriptionWOS: 000393078700016en_US
dc.description.abstractPine oil has antiseptic, expectorant and antioxidant properties and has been used for treatment of rheumatism, respiratory and urinary system and skin diseases. We aimed to determine protective effects of pine oil (PO) on the lipid-soluble vitamins, cholesterol, GSH, total protein, MDA, fatty acid levels of brain tissue of the streptozotocin-induced diabetic rats. Rats were randomly divided into three groups: Control (C), streptozotocin (STZ), streptozotocin+pine oil (PO) groups. Streptozotocin was injected intraperitoneally single dose (65 mg/kg) to the STZ and PO groups for inducing of diabetes. To the PO group 1 mg/kg dose pine oil was intraperitoneally injected every next day. While the GSH and total protein were significantly decreased in the Streptozotocin (STZ) group, their levels were protected in PO group. MDA level was significantly increased in STZ group, its level significantly decreased in the PO group. Our results showed that PO has a positive effect on the GSH, total protein, and MDA levels in the brain tissue of diabetic rats. The PO and STZ administrations were affected by levels of some important fatty acids. The decrease in the MDA level and observed protecting effects can be attributed to PO extract, because it contains some important phytochemical constituents.en_US
dc.description.sponsorshipUniversity of Firat scientific research projects [FF.11.39]en_US
dc.description.sponsorshipThis work was supported by the University of Firat (FF.11.39) scientific research projects.en_US
dc.identifier.endpage1180en_US
dc.identifier.issn0253-5106
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1174en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4613
dc.identifier.volume38en_US
dc.identifier.wosWOS:000393078700016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherChem Soc Pakistanen_US
dc.relation.ispartofJournal Of The Chemical Society Of Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectPine oilen_US
dc.subjectMDAen_US
dc.subjectGlutathioneen_US
dc.subjectCholesterolen_US
dc.subjectBrainen_US
dc.titleSome Positive Effects of Pine Oil on Brain Tissue in Streptozotocin-Induced Diabetic Ratsen_US
dc.typeArticleen_US

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