Prolonged elevation of magnesium in the cerebrospinal fluid of patients with severe head injury

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dc.contributor.authorKafadar, Ali Metin
dc.contributor.authorSanus, Galip Zihni
dc.contributor.authorİş, Merih
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorTanrıverdi, Taner
dc.contributor.authorHanımoğlu, Hakan
dc.contributor.authorUzan, Mustafa
dc.date.accessioned2020-04-30T23:21:47Z
dc.date.available2020-04-30T23:21:47Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKafadar, Ali/0000-0002-3312-3192; Coskun, Abdurrahman/0000-0002-1273-0604; Sanus, Galip Zihni/0000-0001-6539-7254; Uzan, Mustafa/0000-0001-7214-380Xen_US
dc.descriptionWOS: 000252022100010en_US
dc.descriptionPubMed: 17553217en_US
dc.description.abstractObjectives: Several works have investigated the role of serum magnesium (Mg) concentrations in traumatic brain injury. However, there is restricted information about cerebrospinal fluid (CSF) levels of Mg in patients with severe head injury (SHI). We assessed the changes of Mg concentrations in CSF and serum in patients with SHI during the first 10 days after the trauma. Methods: Eleven patients with SHI were studied prospectively on days 1-3, 5 and 10 with analysis of CSF and serum levels of Mg and Ca. The control group consisted of nine patients with hydrocephalus. Results: CSF levels of Mg were significantly higher in patients than controls in the corresponding time points except on days 5 and 10 of trauma. The CSF Mg levels tended to decrease and the highest level was found on day 1 after trauma (2.81 +/- 0.65 mg/dl). In the control group, the CSF level of Mg was 1.95 +/- 0.66 mg/dl. No significant difference can be detected between controls and patients regarding serum Mg and Ca levels. In addition, significantly higher values of Ca in the CSF were observed in all time points after trauma in patients with SHI than in the controls. There was no correlation between the CSF and serum levels of Mg and Ca levels. Discussion: Our study demonstrates that in patients with SHI, CSF levels of Mg and Ca are elevated during the whole observation period. Further works should be designed in order to show the role and importance of CSF levels of ionized Mg in outcome of patients with SHI.en_US
dc.identifier.doi10.1179/016164107X181879en_US
dc.identifier.endpage829en_US
dc.identifier.issn0161-6412
dc.identifier.issn1743-1328
dc.identifier.issue8en_US
dc.identifier.startpage824en_US
dc.identifier.urihttps://doi.org/10.1179/016164107X181879
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4250
dc.identifier.volume29en_US
dc.identifier.wosWOS:000252022100010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNeurological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcalciumen_US
dc.subjectcerebrospinal fluiden_US
dc.subjecthead injuryen_US
dc.subjectmagnesiumen_US
dc.titleProlonged elevation of magnesium in the cerebrospinal fluid of patients with severe head injuryen_US
dc.typeArticleen_US

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