Fabrication of curcumin-loaded magnetic PEGylated-PLGA nanocarriers tagged with GRGDS peptide for improving anticancer activity

Basit Öğe Kaydı
dc.authoridÇakmak, Soner/0000-0003-2245-8322en_US
dc.authoridSenturk, Fatih/0000-0002-2436-3362en_US
dc.authorscopusid57223847596en_US
dc.authorscopusid26533899000en_US
dc.authorwosidÇakmak, Soner/I-4478-2015en_US
dc.authorwosidSenturk, Fatih/AEI-3613-2022en_US
dc.contributor.authorSenturk, Fatih
dc.contributor.authorCakmak, Soner
dc.date.accessioned2024-08-23T16:04:41Z
dc.date.available2024-08-23T16:04:41Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractCarrier-mediated drug delivery systems are highly promising as a treatment option for the targeted delivery of potent cytotoxic drugs with increased efficacy and safety. Considering that poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) polymers each provide certain advantages for biological purposes, PEGylated-PLGA nanoparticles have emerged as a leading candidate among other alternatives. Furthermore, these nanoparticles can be modified with the specific short peptide sequences such as glycine-arginine-glycine-aspartic acid -serine (GRGDS), which selectively binds to integrins overexpressed in most cancer cells, allowing for targeted delivery. Here, we reported the details in fabrication and characterization of magnetic PEGylated-PLGA nanoparticles functionalized with GRGDS peptide. In addition, superparamagnetic iron oxide nanoparticles (SPIONs) and the natural pharmaceutical compound curcumin (Cur) were loaded into these polymeric nanoparticles to assess their anticancer activity potential. Overall, this study provides comprehensive methodologies, including all synthesis procedures, challenges, and useful suggestions for peptide-conjugated polymeric nanoparticles that may be used for cellular targeting and therapeutic applications.& BULL; Step by step fabrication protocol for the Cur loaded magnetic PEGylated-PLGA nanoparticles was presented.& BULL; Validation of the fabrication and the GRGDS conjugation to the nanoparticles were shown via detailed characterization studies.& BULL; The cytotoxic effect of the Cur-loaded and GRGDS-tagged magnetic nanoparticles was tested on T98G glioblastoma cell line as a preliminary in vitro study.en_US
dc.description.sponsorshipScientific and Technological Research Council of Tuuml;rkiye (TUBITAK) [SBAG-119S137]; [SBAG-118S027]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Tuerkiye (TUBITAK) , Grant no: SBAG-118S027 and SBAG-119S137. We are sincerely grateful for the assistance of the Cell and Tissue Engineering Research Group at Hacettepe University under the supervision of Prof. Dr. Menemse Gumusderelioglu.en_US
dc.identifier.doi10.1016/j.mex.2023.102229
dc.identifier.issn2215-0161
dc.identifier.pmid37292239en_US
dc.identifier.scopus2-s2.0-85161054182en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.mex.2023.102229
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14302
dc.identifier.volume10en_US
dc.identifier.wosWOS:001054348200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMethodsxen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPLGAen_US
dc.subjectGRGDSen_US
dc.subjectMagnetic polymeric nanoparticlesen_US
dc.subjectCellular targetingen_US
dc.subjectIron-Oxide Nanoparticlesen_US
dc.subjectPaclitaxelen_US
dc.subjectReleaseen_US
dc.titleFabrication of curcumin-loaded magnetic PEGylated-PLGA nanocarriers tagged with GRGDS peptide for improving anticancer activityen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu