Novel tetrazole and 1,3,4-oxadiazole derivatives synthesis, molecular docking, Adme, potential activator for rabbit muscle pyruvate kinase

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dc.authorscopusid55342808300en_US
dc.authorscopusid37099630300en_US
dc.authorscopusid59002471300en_US
dc.authorscopusid57191499641en_US
dc.authorscopusid57224659920en_US
dc.authorscopusid57203542863en_US
dc.contributor.authorKaya, M.O.
dc.contributor.authorDemirci, T.
dc.contributor.authorKaripçin, S.
dc.contributor.authorÖzdemir, O.
dc.contributor.authorKaya, Y.
dc.contributor.authorArslan, M.
dc.date.accessioned2024-08-23T16:07:29Z
dc.date.available2024-08-23T16:07:29Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe activation of muscle pyruvate kinase (PK) increases the conversion of phosphoenolpyruvate (PEP) to pyruvate, which results in the production of ATP. This is critical for supplying the energy needed for muscle contraction. In this study, we synthesized 1,4-dihydropyridine/pyridine compounds bearing tetrazole and 1,3,4-oxadiazole groups by using Hantzsch method and characterized by FT-IR spectroscopy, elemental analysis, and 1 H and13C NMR and studied PK activation, ADME, and molecular docking. The studies revealed that all original synthesized compounds activated PK and AC50 (half-maximal activating concentration) values of the compounds were extremely effective (1.30 µM to 14.65 µM). © 2024, Babes-Bolyai University. All rights reserved.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAKen_US
dc.identifier.doi10.24193/subbchem.2024.1.06
dc.identifier.endpage105en_US
dc.identifier.issn1224-7154
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85191355155en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.24193/subbchem.2024.1.06
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14675
dc.identifier.volume2024en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBabes-Bolyai Universityen_US
dc.relation.ispartofStudia Universitatis Babes-Bolyai Chemiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject1,3,4-oxadiazoleen_US
dc.subjectRabbit Muscle Pyruvate Kinaseen_US
dc.subjectTetrazoleen_US
dc.titleNovel tetrazole and 1,3,4-oxadiazole derivatives synthesis, molecular docking, Adme, potential activator for rabbit muscle pyruvate kinaseen_US
dc.typeArticleen_US

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