Novel tetrazole and 1,3,4-oxadiazole derivatives synthesis, molecular docking, Adme, potential activator for rabbit muscle pyruvate kinase
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Babes-Bolyai University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The activation of muscle pyruvate kinase (PK) increases the conversion of phosphoenolpyruvate (PEP) to pyruvate, which results in the production of ATP. This is critical for supplying the energy needed for muscle contraction. In this study, we synthesized 1,4-dihydropyridine/pyridine compounds bearing tetrazole and 1,3,4-oxadiazole groups by using Hantzsch method and characterized by FT-IR spectroscopy, elemental analysis, and 1 H and13C NMR and studied PK activation, ADME, and molecular docking. The studies revealed that all original synthesized compounds activated PK and AC50 (half-maximal activating concentration) values of the compounds were extremely effective (1.30 µM to 14.65 µM). © 2024, Babes-Bolyai University. All rights reserved.
Açıklama
Anahtar Kelimeler
1,3,4-oxadiazole, Rabbit Muscle Pyruvate Kinase, Tetrazole
Kaynak
Studia Universitatis Babes-Bolyai Chemia
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
2024
Sayı
1
