The Evaluation of the Genetic Variation Types of the Uridine Diphosphate Glucuronosyl Transferase 1A1 Gene by Next-Generation Sequencing and Their Effects on Bilirubin Levels in Obese Children

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dc.authorscopusid59188707300en_US
dc.authorscopusid57193504841en_US
dc.authorscopusid34868115100en_US
dc.authorscopusid6602733795en_US
dc.contributor.authorAslantas, Merve
dc.contributor.authorKilicaslan, Onder
dc.contributor.authorEroz, Recep
dc.contributor.authorKocabay, Kenan
dc.date.accessioned2024-08-23T16:04:20Z
dc.date.available2024-08-23T16:04:20Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground and Objectives: Obesity is a major nutritional problem with an increasing prevalence among children and adolescents. The uridine-diphosphate-glucuronosyl-transferase1A1 (UGT1A1) gene encodes the UDP-glucuronosyl transferase enzyme, converting the toxic form of bilirubin to a soluble, nontoxic form. There are yet to be studies on the evaluation of the UGT1A1 variant types detected by next-generation sequencing (NGS) and their effects on bilirubin levels in nonsyndromic obese children. Methods: Forty-five children with body mass index (BMI) >95 percentile (p) constituted the obesity group and fourteen healthy children with BMI <85p constituted the control group. Anthropometric, clinical features, and biochemical parameters were evaluated. Furthermore, the UGT1A1 gene was sequenced by NGS. Results: The obese patients had lower total, direct, and indirect bilirubin levels (p = 0.422, 0.026, and 0.568, respectively). In addition, obese patients had more genetic variations in the UGT1A1 gene compared with the control group (62.2% and 50%, respectively). We found that children with variations had higher total direct and indirect bilirubin levels compared with those without variation (p = 0.016, 0.028, and 0.015, respectively). Children diagnosed with obesity in the first two years of their life had fewer genetic variations and lower total bilirubin levels (p = 0.000 and 0.013, respectively). Conclusions: It is assumed that bilirubin can be protective against many chronic diseases. Although bilirubin levels are found to be lower in obese children compared with the control group, some variations in the UGT1A1 gene may be supported by raising bilirubin. We suggest that high bilirubin levels caused by those UGT1A1 variations may be protective against obesity and its many negative effects.en_US
dc.description.sponsorshipDuzce University [DUBAP2018.04.03.797]en_US
dc.description.sponsorshipThis work was supported by Duzce University, Project No: DUBAP2018.04.03.797.en_US
dc.identifier.doi10.1089/gtmb.2023.0365
dc.identifier.endpage280en_US
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue7en_US
dc.identifier.pmid38916116en_US
dc.identifier.scopus2-s2.0-85196886834en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1089/gtmb.2023.0365
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14175
dc.identifier.volume28en_US
dc.identifier.wosWOS:001253734100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofGenetic Testing And Molecular Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbilirubinen_US
dc.subjectchildhooden_US
dc.subjectgeneticen_US
dc.subjectnext-generation sequenceen_US
dc.subjectobesityen_US
dc.subjectugt1a1en_US
dc.subjectSerum Bilirubinen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectChildhood Obesityen_US
dc.subjectAssociationen_US
dc.subjectWeighten_US
dc.subjectRisken_US
dc.titleThe Evaluation of the Genetic Variation Types of the Uridine Diphosphate Glucuronosyl Transferase 1A1 Gene by Next-Generation Sequencing and Their Effects on Bilirubin Levels in Obese Childrenen_US
dc.typeArticleen_US

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