Regression of the Carotid Intima Media Thickness by Propylthiouracil Therapy in Graves' Hyperthyroidism

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dc.contributor.authorBilir, Cemil
dc.contributor.authorGökosmanoğlu, Feyzi
dc.contributor.authorÇalışkan, Mustafa
dc.contributor.authorCinemre, Hakan
dc.contributor.authorAkdemir, Ramazan
dc.date.accessioned2020-04-30T23:31:35Z
dc.date.available2020-04-30T23:31:35Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionBilir, Cemil/0000-0002-1372-4791en_US
dc.descriptionWOS: 000302158400002en_US
dc.descriptionPubMed: 21825964en_US
dc.description.abstractIntroduction: One of the cardiovascular effects of hyperthyroidism is increased carotid intima media thickness (CIMT). The aim of this study is to investigate the CIMT in patients with Graves' hyperthyroidism and the effect of propylthiouracil (PTU) therapy on CIMT. Method: Twenty-six patients with Graves' hyperthyroidism and 33 healthy controls were included in the study. CIMT was measured at the right and left external carotid arteries in every patient in both groups. CIMT was measured before and after the PTU therapy in patients with Graves' hyperthyroidism. Results: There was a significant difference in CIMT between the group of Graves' hyperthyroid patients and the control group (0.72 versus 0.55 mm, P < 0.0001) at baseline. Twenty-five of 26 patients with Graves' disease were followed up for 18 months prospectively. Euthyroidism has been achieved in 21 patients. After 18 months of treatment, CIMT decreased significantly compared with the baseline values [0.84 (0.54-1.3) to 0.72 (0.50-1.2), change 0.12 mm, P < 0.001]. Conclusion: Graves' hyperthyroidism is associated with atherosclerosis as assessed by CIMT. Treatment of Graves' hyperthyroidism with PTU decreases the CIMT.en_US
dc.identifier.doi10.1097/MAJ.0b013e31822a8284en_US
dc.identifier.endpage276en_US
dc.identifier.issn0002-9629
dc.identifier.issn1538-2990
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.1097/MAJ.0b013e31822a8284
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4334
dc.identifier.volume343en_US
dc.identifier.wosWOS:000302158400002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAmerican Journal Of The Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarotid intima media thicknessen_US
dc.subjectPropylthiouracilen_US
dc.subjectGraves' diseaseen_US
dc.subjectRegressionen_US
dc.titleRegression of the Carotid Intima Media Thickness by Propylthiouracil Therapy in Graves' Hyperthyroidismen_US
dc.typeArticleen_US

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