INVESTIGATION OF TIGECYCLINE SUSCEPTIBILITY OF MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII ISOLATES BY DISC DIFFUSION, AGAR GRADIENT AND BROTH MICRODILUTION TESTS

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dc.contributor.authorÇalışkan, Emel
dc.contributor.authorİnce, Nevin
dc.contributor.authorAkar, Nida
dc.contributor.authorÖztürk, Cihadiye Elif
dc.date.accessioned2023-07-26T11:54:34Z
dc.date.available2023-07-26T11:54:34Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractThe use of tigecycline is becoming increasingly important because of the high levels of antibiotic resistance in Acinetobacter baumannii (A. baumannii) isolates. In this prospective study, multidrug-resistant A. baumannii isolates were obtained from various tissue and fluid samples of patients admitted to or treated at various departments and tested in Laboratory of Microbiology, Duzce University Medical Faculty between January 2013 and December 2015. Tigecycline resistance in multidrug-resistant A. baumannii isolates were analyzed using the disc diffusion test (DDT), agar gradient test (AGT), and gold standard test [broth microdilution test (BMT)]. A. baumannii isolates resistant to multiple drugs were included in the study (N=94). Using the BMT method, 89 (95%), 4 (4%) and 1 (1%) A. baumannii isolates were determined as tigecycline susceptible, intermediate and resistant isolates, respectively. Using the Food and Drug Administration criteria, the rates of major error (ME), minor error (mE) and categorical agreement (CA) for DDT were 26%, 67% and 9%, respectively. In contrast, for AGT, the rates of ME, mE and CA were 0%, 4%, 95%, respectively. Tigecycline resistance as assessed by BMT showed no increase between 2013 and 2015. Accordingly, isolates found to be resistant or intermediate by DDT should be confirmed by BMT. Due to the ease of application, AGT is a safe method of detecting susceptibility.en_US
dc.identifier.doi10.20471/acc.2022.61.01.06
dc.identifier.endpage51en_US
dc.identifier.issn0353-9466
dc.identifier.issn1333-9451
dc.identifier.issue1en_US
dc.identifier.pmid36398087en_US
dc.identifier.scopus2-s2.0-85134478976en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.20471/acc.2022.61.01.06
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12868
dc.identifier.volume61en_US
dc.identifier.wosWOS:000830078200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇalışkan, Emel
dc.institutionauthorÖztürk, Cihadiye Elif
dc.institutionauthorİnce, Nevin
dc.language.isoenen_US
dc.publisherSestre Milosrdnice Univ Hospitalen_US
dc.relation.ispartofActa Clinica Croaticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAcinetobacter Baumannii; Agar Gradient Test; Broth Microdilution Test; Disc Diffusion Test; Multidrug-Resistance; Tigecyclineen_US
dc.subjectAntimicrobial Susceptibility; Infection; Outbreaken_US
dc.titleINVESTIGATION OF TIGECYCLINE SUSCEPTIBILITY OF MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII ISOLATES BY DISC DIFFUSION, AGAR GRADIENT AND BROTH MICRODILUTION TESTSen_US
dc.title.alternativeISPITIVANJE OSJETLJIVOSTI NA TIGECIKLIN MULTIREZISTENTNIH IZOLATA ACINETOBACTER BAUMANNII TESTOVIMA DISK DIFUZIJE, AGAR GRADIJENTA I MIKRODILUCIJE U BUJONUen_US
dc.typeArticleen_US

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