Dynamic Changes in Perioperative Cellular Inflammation and Acute Kidney Injury after Coronary Artery Bypass Grafting

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dc.authoridArikan, Ali Ahmet/0000-0002-9599-1577
dc.authorwosidArikan, Ali Ahmet/AAA-1121-2020
dc.contributor.authorParlar, Hakan
dc.contributor.authorArikan, Ali Ahmet
dc.contributor.authorOnmez, Attila
dc.date.accessioned2021-12-01T18:48:59Z
dc.date.available2021-12-01T18:48:59Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractIntroduction: This study investigated the role of the neutrophillymphocyte ratio (NLR), the perioperative changes in NLR (deltaNLR), the platelet-lymphocyte ratio (PLR), and the platelet count in predicting acute kidney injury (AKI) following coronary artery bypass grafting (CABG) during hospital stay. Methods: The records of 396 patients with preoperative creatinine < 1.5 mg/dl undergoing isolated CABG between October 2015 and October 2019 were reviewed retrospectively. Diagnosis of AKI was based on the Kidney Disease Improving Global Outcomes definition. Demographic data, operative data, inhospital mortality, preoperative NLR, PLR, and platelet counts were compared between patients with (AKI group) and without (nonAKI group) postoperative AKI. Additionally, NLR, delta-NLR, and PLR values were calculated daily for the first four postoperative days. A subsequent AKI group was formed for the first four postoperative days by excluding patients diagnosed with AKI. The daily and overall predictivity of the markers for AKI are investigated. Results: AKI was present in 86 patients during the postoperative period, while 310 patients had normal postoperative renal functions. NLR, delta-NLR, and PLR on the first four postoperative days (P<0.001 for all) were significantly associated with the development of AKI in subsequent days. Multivariate analysis identified postoperative NLR (odds ratio 1.17, 95% confidence interval 1.11-1.23; P<0.001) as an independent predictor of AKI. PLR lost its significant association with AKI at the values measured at discharge from hospital (P>0.05). Conclusion: NLR values measured on the first four days postoperatively are a useful tool in predicting AKI during hospital stay following CABG.en_US
dc.identifier.doi10.21470/1678-9741-2020-0163
dc.identifier.endpage364en_US
dc.identifier.issn0102-7638
dc.identifier.issn1678-9741
dc.identifier.issue3en_US
dc.identifier.pmid34387973en_US
dc.identifier.scopus2-s2.0-85112676294en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage354en_US
dc.identifier.urihttps://doi.org/10.21470/1678-9741-2020-0163
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10643
dc.identifier.volume36en_US
dc.identifier.wosWOS:000674648100011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Brasil Cirurgia Cardiovascen_US
dc.relation.ispartofBrazilian Journal Of Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary Artery Bypassen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectNeutrophilsen_US
dc.subjectLymphocytesen_US
dc.subjectPlatelet Counten_US
dc.subjectLength of Stayen_US
dc.subjectPatient Dischargeen_US
dc.subjectTo-Lymphocyte Ratioen_US
dc.subjectCardiac-Surgeryen_US
dc.subjectNeutrophilen_US
dc.subjectPlateleten_US
dc.titleDynamic Changes in Perioperative Cellular Inflammation and Acute Kidney Injury after Coronary Artery Bypass Graftingen_US
dc.typeArticleen_US

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