The platelet indices in patients with rheumatoid arthritis: Mean platelet volume reflects disease activity

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dc.contributor.authorYazıcı, Selma
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorErer, Burak
dc.contributor.authorErer, Betül
dc.contributor.authorÇalık, Yalkın
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorAtaoğlu, Safinaz
dc.date.accessioned2020-04-30T23:34:00Z
dc.date.available2020-04-30T23:34:00Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000274880600006en_US
dc.descriptionPubMed: 20050760en_US
dc.description.abstractThe present study was designed to investigate the interaction between platelet indices, inflammatory markers and disease activity in rheumatoid arthritis (RA) subjects. The effects of anti-TNF-alpha therapy and conventional treatment on platelet indices were also compared. We studied 97 patients with RA (19 men, 78 women: mean age 51 years) and 33 age and sex-matched healthy subjects as a control group. All RA patients were administered conventional therapy. After 3 months of therapy, 35 subjects who had high disease activity score (DAS28 > 5.1) were grouped as non-responders and were administered infliximab as a TNF-alpha blocker at the standard intravenous dose. Responders to the conventional therapy and non-responders were also compared. At baseline white blood cell (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelet count and mean platelet volume (MPV) were significantly higher in patients with RA. Mean platelet volume was positively correlated with DAS28 score (r = 0.27; p = 0.007). These markers of inflammation and platelet indices were substantially decreased after therapy. The reductions were similar in responders to conventional therapy and non-responders (TNF alpha group). In conclusion, we found that MPV was correlated with inflammatory markers and disease activity in patients with RA. Both anti-TNF-alpha and conventional therapy decreases markers of inflammation and platelet indices. MPV can reflect both disease activity and response to treatment.</.en_US
dc.identifier.doi10.3109/09537100903474373en_US
dc.identifier.endpage125en_US
dc.identifier.issn0953-7104
dc.identifier.issn1369-1635
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.3109/09537100903474373
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5086
dc.identifier.volume21en_US
dc.identifier.wosWOS:000274880600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofPlateletsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMean platelet volumeen_US
dc.subjectrheumatoid arthritisen_US
dc.titleThe platelet indices in patients with rheumatoid arthritis: Mean platelet volume reflects disease activityen_US
dc.typeArticleen_US

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