Frequency of Hepatosteatosis and Relationship Between Laboratory Parameters and Hepatosteatosis in Chronic Hepatitis B Patients

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dc.authoridOz, Murtaza/0000-0003-3415-5927en_US
dc.authoridBUYUKTUNA, SEYIT ALI/0000-0001-6518-7361en_US
dc.contributor.authorCakir, Yasemin
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorOez, Murtaza
dc.contributor.authorBueyuektuna, Seyit Ali
dc.date.accessioned2024-08-23T16:03:26Z
dc.date.available2024-08-23T16:03:26Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjectives: Hepatosteatosis is very common worldwide and is defined as the accumulation of lipid droplets in hepatocytes. Hepatosteatosis is often associated with metabolic factors such as obesity, insulin resistance, and hypertriglyceridemia. The relationship between chronic hepatitis B (CHB) and hepatosteatosis remains unknown. We investigated the frequency of hepatosteatosis in patients with CHB and to evaluate the relationship between hepatosteatosis and laboratory parameters. Materials and Methods: We retrospectively studied 262 patients with CHB. Patients were divided into two groups, hepatosteatosis and non-hepatosteatosis, according to liver ultrasonography findings. The groups were compared in terms of demographic characteristics and laboratory parameters. Results: A total of 262 patients with CHB were included. The mean age was 45.1 +/- 15.3 years, 136 (51.8%) of whom were male. Liver biopsy was performed in 86 (32.8%) of the patients, 20 (7.6%) had fibrosis, and 163 (62.2%) had steatosis. Among the patients with steatosis, grade 1 steatosis was observed in 30.9 (81/163), grade 2 in 26 (68/163), and grade 3 in 5.3 (14/163). Hypertension, hepatomegaly, and cirrhosis were correlated with the presence of steatosis. Patients with steatosis were older than those without. Fasting glucose levels, low-density lipoprotein levels, and triglyceride levels of patients with steatosis were higher than those of patients without steatosis. High-density lipoprotein levels were lower in the steatosis group. No correlation has been found with gender, body mass index, hepatitis delta virus co -infection, hepatitis B virus (HBV)-DNA levels, or hepatitis B e antigen status between steatosis. Conclusion: We found that hepatosteatosis is present in a significant proportion of patients with CHB. Although the presence of hepatosteatosis was associated with some metabolic parameters, the relationship between it and HBV parameters was not statistically significant.en_US
dc.identifier.doi10.4274/vhd.galenos.2024.2023-12-2
dc.identifier.endpage12en_US
dc.identifier.issn1307-9441
dc.identifier.issn2147-2939
dc.identifier.issue1en_US
dc.identifier.startpage7en_US
dc.identifier.trdizinid1242331en_US
dc.identifier.urihttps://doi.org/10.4274/vhd.galenos.2024.2023-12-2
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1242331
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13754
dc.identifier.volume30en_US
dc.identifier.wosWOS:001229804000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofViral Hepatit Dergisi-Viral Hepatitis Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCirrhosisen_US
dc.subjecthepatitis Ben_US
dc.subjectnon-alcoholic fatty liver diseasesen_US
dc.subjectFatty Liver-Diseaseen_US
dc.subjectGlobal Epidemiologyen_US
dc.subjectPrevalenceen_US
dc.subjectSteatosisen_US
dc.subjectProgressionen_US
dc.subjectTurkeyen_US
dc.subjectCohorten_US
dc.subjectImpacten_US
dc.titleFrequency of Hepatosteatosis and Relationship Between Laboratory Parameters and Hepatosteatosis in Chronic Hepatitis B Patientsen_US
dc.typeArticleen_US

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