Effect of low-dose acitretin treatment on pituitary hormones in psoriasis vulgaris: A retrospective study

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dc.contributor.authorKaradağ, Ayşe Serap
dc.contributor.authorÖzlü, Emin
dc.contributor.authorKöstek, Osman
dc.contributor.authorBilgili, Serap Güneş
dc.contributor.authorBalaharoğlu, Ragıp
dc.contributor.authorErtuğrul, Derun Taner
dc.date.accessioned2020-05-01T09:11:42Z
dc.date.available2020-05-01T09:11:42Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKostek, Osman/0000-0002-1901-5603en_US
dc.descriptionWOS: 000465637900011en_US
dc.descriptionPubMed: 29855455en_US
dc.description.abstractBackground: It has been reported that retinoids may lead to hormonal alterations. Aim: In this retrospective study, we aimed to study the effect of acitretin on pituitary hormones in psoriasis patients. Methods: Out of 50 patients intended to be studied, blood samples of 43 patients could be tested before and after 3 months of acitretin therapy (0.2 to 0.5 mg/kg/day). Results: Patients mean +/- standard deviation ages and female/male ratio were 46 +/- 17 years and 19/24, respectively. After treatment with acitretin, gamma-glutamyltransferase, alkaline phosphatase, total cholesterol and triglyceride levels increased significantly (P < 0.05). After treatment, total protein, free thyroxine (T4) levels decreased significantly (P < 0.05). No significant differences were observed between before-after acitretin treatment regarding pituitary hormone levels in psoriasis patients (P > 0.05). Limitations: The retrospective nature of the study, inability to retest blood samples of 7 patients at 3 months post treatment, low dose and short duration of acitretin treatment were limitations of this study. Conclusion: This study showed that pituitary hormones were not affected except free T4 (thyroid hormone) by acitretin treatment. Further experimental and clinical studies are needed to clarify the effect of acitretin on pituitary hormones.en_US
dc.identifier.doi10.4103/ijdvl.IJDVL_628_17
dc.identifier.endpage304en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage300en_US
dc.identifier.urihttps://doi.org/10.4103/ijdvl.IJDVL_628_17
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5733
dc.identifier.volume85en_US
dc.identifier.wosWOS:000465637900011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Dermatology Venereology & Leprologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPituitary hormonesen_US
dc.subjectpsoriasisen_US
dc.subjectretinoidsen_US
dc.subjecttherapeuticsen_US
dc.titleEffect of low-dose acitretin treatment on pituitary hormones in psoriasis vulgaris: A retrospective studyen_US
dc.typeArticleen_US

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