Oxidative Stress and Decrease of Paroxonase Activity in Patients whit Prostate Cancer

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dc.contributor.authorOrhan, Nuri
dc.contributor.authorÖzcan, Muhammet Engin
dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorUçgun, Taner
dc.contributor.authorKayıkçı, Muhammet Ali
dc.contributor.authorDemirin, Hilmi
dc.date.accessioned2020-04-30T23:20:27Z
dc.date.available2020-04-30T23:20:27Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000363103100008en_US
dc.description.abstractObjective: Prostate cancer is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the prostate cancer. The paraoxonase (PON1) is an endogenous antioxidant in the human body. The aim of our study was to determine whether lipid parameters, total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidative stress index (OSG), serum paraoxonase (PON1) and arylesterase (ARE) levels and phenotypes distribution alter new diagnosis in patients with prostate cancer and to compare the values with those of healthy controls. Methods: The study was performed prospective which consist of the prostate cancer group (PC) and healthy control group. Serum PON1, ARE activities, and other parameters were measured in 40 subjects in both groups. The PON1 phenotypes were defined according to the ratio of serum PON1/ARE activity. In statistical evaluation of data was performed by Student t test and Pearson's correlation analysis. Results: TKOL and LDL-K levels were found to be lower in the patients compared to controls (p=0,044; p=0,026). OSI levels in patients was higher than the controls (p=0,029). PON1 and ARE activities were found to be lower in patients compared to the controls (p=0,040; p=0,027). PON1 enzyme activity was determined as three different phenotypes in both groups. In PC group, significant deviation of PON1 phenotype frequencies from Hardy-Weinberg equilibrium was found. Conclusion: The results of our study suggest that oxidative stress, through lipid peroxidation may play an important role for the development of prostate cancer and that PON1, and PON1 phenotyping may be predictive for prostate cancer.en_US
dc.identifier.endpage117en_US
dc.identifier.issn1309-3878
dc.identifier.issue2en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4011
dc.identifier.volume7en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherDuzce Univen_US
dc.relation.ispartofKonuralp Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectLipid Peroxidationen_US
dc.subjectParaoxonaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectProstate Canceren_US
dc.titleOxidative Stress and Decrease of Paroxonase Activity in Patients whit Prostate Canceren_US
dc.typeArticleen_US

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