Further Evidence for the Role of Nitric Oxide in Maternal Aggression: Effects of L-NAME on Maternal Aggression towards Female Intruders in Wistar Rats

Basit Öğe Kaydı
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorMarangoz, Cafer
dc.date.accessioned2020-05-01T12:10:08Z
dc.date.available2020-05-01T12:10:08Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Seyit/0000-0003-3752-0846; Ankarali, Handan Camdeviren/0000-0002-3613-0523en_US
dc.descriptionWOS: 000270857000015en_US
dc.descriptionPubMed: 18657004en_US
dc.description.abstractIt has been shown that nitric oxide (NO) increases aggression in male mice, whereas it decreases aggression in lactating female mice and prairie voles. It is also known that aggression can be exhibited at different levels in rodent species, strain or subtypes. The aims of this study were to investigate the proportion of aggressiveness in Wistar rats, the effect of intraperitoneally administered nonspecific nitric oxide synthase (NOS) inhibitor L-NAME (N-G-nitro L-arginine methyl ester) on maternal aggression towards female intruders, and whether these effects are due to NO production or not. Rats were given saline intraperitoneally on the postpartum Day 2 and aggression levels were recorded. The same rats were given 60 mg/kg L-NAME or D-NAME (N-G-nitro D-arginine methyl ester) on the postpartum Day 3 and their effects on aggression levels were compared to saline. While L-NAME administration did not cause any differences in the total number of aggressive behavior, aggression duration and aggression intensity, it reduced the proportion of animals showing aggressive behavior. In addition, the latency of the first aggression was significantly increased by L-NAME. In the D-NAME group, however, no significant change was found. Our results have shown that L-NAME reduces maternal aggression towards female intruders in Wistar rats through inhibition of NO production. These results suggest that the role of NO in offensive and defensive maternal aggression shares neural mechanisms.en_US
dc.identifier.endpage598en_US
dc.identifier.issn0862-8408
dc.identifier.issn1802-9973
dc.identifier.issue4en_US
dc.identifier.startpage591en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6025
dc.identifier.volume58en_US
dc.identifier.wosWOS:000270857000015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcad Sciences Czech Republic, Inst Physiologyen_US
dc.relation.ispartofPhysiological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMaternal aggressionen_US
dc.subjectNitric oxideen_US
dc.subjectN-G-nitro L-arginine methyl esteren_US
dc.subjectWistar raten_US
dc.titleFurther Evidence for the Role of Nitric Oxide in Maternal Aggression: Effects of L-NAME on Maternal Aggression towards Female Intruders in Wistar Ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
6025.pdf
Boyut:
829.33 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu