Comprehensive bronchoalveolar lavage characterization in COVID-19 associated acute respiratory distress syndrome patients: a prospective cohort study

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dc.authoridEmilian, Olteanu Gheorghe/0000-0001-5921-4634en_US
dc.authoridFortarezza, Francesco/0000-0002-8954-5888en_US
dc.authoridCATTELAN, ANNA MARIA/0000-0003-2869-2945en_US
dc.authoridGregori, Dario/0000-0001-7906-0580en_US
dc.authoridNavalesi, Paolo/0000-0002-3733-3453en_US
dc.authoridDEL VECCHIO, CLAUDIA/0000-0001-5645-9126en_US
dc.authorscopusid57225782312en_US
dc.authorscopusid24779771700en_US
dc.authorscopusid57194266695en_US
dc.authorscopusid57203385065en_US
dc.authorscopusid56495523600en_US
dc.authorscopusid58079140900en_US
dc.authorscopusid15028054200en_US
dc.authorwosidEmilian, Olteanu Gheorghe/AAK-4856-2020en_US
dc.authorwosidFortarezza, Francesco/AAY-2994-2020en_US
dc.authorwosidGregori, Dario/F-9974-2012en_US
dc.authorwosidCATTELAN, ANNA MARIA/AAL-3654-2020en_US
dc.authorwosidNavalesi, Paolo/I-9584-2019en_US
dc.contributor.authorCalabrese, Fiorella
dc.contributor.authorLunardi, Francesca
dc.contributor.authorBaldasso, Elisa
dc.contributor.authorPezzuto, Federica
dc.contributor.authorKilitci, Asuman
dc.contributor.authorOlteanu, Gheorghe-Emilian
dc.contributor.authorDel Vecchio, Claudia
dc.date.accessioned2024-08-23T16:04:05Z
dc.date.available2024-08-23T16:04:05Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractCOVID-19-related acute respiratory distress syndrome (CARDS) is associated with high mortality rates. We still have limited knowledge of the complex alterations developing in the lung microenvironment. The goal of the present study was to comprehensively analyze the cellular components, inflammatory signature, and respiratory pathogens in bronchoalveolar lavage (BAL) of CARDS patients (16) in comparison to those of other invasively mechanically ventilated patients (24). In CARDS patients, BAL analysis revealed: SARS-CoV-2 infection frequently associated with other respiratory pathogens, significantly higher neutrophil granulocyte percentage, remarkably low interferon-gamma expression, and high levels of interleukins (IL)-1 beta and IL-9. The most important predictive variables for worse outcomes were age, IL-18 expression, and BAL neutrophilia. To the best of our knowledge, this is the first study that was able to identify, through a comprehensive analysis of BAL, several aspects relevant to the complex pathophysiology of CARDS.en_US
dc.description.sponsorshipGILEAD Fellowship Program 2021; University of Padova (Intesa San Paolo Vita bank) for young pathologists [2020A08]en_US
dc.description.sponsorshipThe research was partially funded by the GILEAD Fellowship Program 2021 and by fellowships from the University of Padova (Intesa San Paolo Vita bank) for young pathologists (FF, EGO), without any role in the design of the study, analysis and interpretation of the data (2020A08).en_US
dc.identifier.doi10.1186/s12931-023-02464-9
dc.identifier.issn1465-993X
dc.identifier.issue1en_US
dc.identifier.pmid37296478en_US
dc.identifier.scopus2-s2.0-85163077415en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12931-023-02464-9
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14065
dc.identifier.volume24en_US
dc.identifier.wosWOS:001005565900002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofRespiratory Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectARDSen_US
dc.subjectBronchoalveolar lavageen_US
dc.subjectCOVID-19en_US
dc.subjectCytokine profileen_US
dc.subjectMicrobiologyen_US
dc.subjectManagementen_US
dc.titleComprehensive bronchoalveolar lavage characterization in COVID-19 associated acute respiratory distress syndrome patients: a prospective cohort studyen_US
dc.typeArticleen_US

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