Hyperbaric oxygen therapy prevents subarachnoid hemorrhage-induced apoptosis and impaired contractility of the rabbit bladder

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dc.authoridMirasoglu, Bengusu/0000-0002-2062-0229
dc.authoridSener, Goksel/0000-0001-7444-6193
dc.authoridCevik, Ozge/0000-0002-9325-3757
dc.authoridCelik, Ozgur/0000-0003-3736-8303
dc.authoridSekerci, Cagri Akin/0000-0002-0334-2466
dc.authorwosidMirasoglu, Bengusu/AAE-7277-2020
dc.authorwosidSener, Goksel/AAN-4461-2021
dc.authorwosidCevik, Ozge/F-1326-2014
dc.authorwosidSekerci, Cagri Akin/I-5566-2015
dc.contributor.authorTinay, Ilker
dc.contributor.authorCelik, Ozgur
dc.contributor.authorSekerci, Cagri Akin
dc.contributor.authorCadirci, Selin
dc.contributor.authorCevik, Ozge
dc.contributor.authorOroglu, Bengusu
dc.contributor.authorTarcan, Tufan
dc.date.accessioned2021-12-01T18:50:38Z
dc.date.available2021-12-01T18:50:38Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractAim To explore the effects of experimental subarachnoid hemorrhage (SAH) on rabbit urinary bladder and to assess the potential protective effects of hyperbaric oxygen therapy (HBOT). Methods A total of 15 male New Zealand white rabbits were divided randomly to one of three groups: group I was spared as the control group (n = 5), group II was exposed to SAH, received no treatment, and acted as the SAH group (n = 5) and group III was exposed to SAH and received five sessions of HBOT (started 12 hours after SAH induction and was given twice daily for the first 2 days and once on the third day) and acted as the treatment group (n = 5). At 72 hours after the SAH induction, bladders from all animals were removed for in vitro organ bath experiments and biochemical analyses. Results Isometric tension studies revealed that compared to group I, the contractile responses of the strips to carbachol in group II were significantly decreased whereas HBOT restored the contractile responses (P < .05). Caspase-3 and nitric oxide synthase (NOS) activities of bladder tissues were significantly increased in group II when compared with group I, whereas caspase-3 and NOS activities were significantly decreased in the tissues of group III (P < .01). Conclusions Subarachnoid hemorrhage stimulates apoptosis of the rabbit bladder and impairs the contractile response of the rabbit bladder to carbachol. HBOT creates a protective effect in rabbit bladder tissues and restores SAH-induced changes.en_US
dc.identifier.doi10.1002/nau.24418
dc.identifier.endpage1282en_US
dc.identifier.issn0733-2467
dc.identifier.issn1520-6777
dc.identifier.issue5en_US
dc.identifier.pmid32483860en_US
dc.identifier.scopus2-s2.0-85085891785en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1276en_US
dc.identifier.urihttps://doi.org/10.1002/nau.24418
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10906
dc.identifier.volume39en_US
dc.identifier.wosWOS:000536779200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofNeurourology And Urodynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjecthyperbaric oxygene therapyen_US
dc.subjectsubarachnoid heamorrhageen_US
dc.subjecturinary bladderen_US
dc.subjectCerebral-Ischemiaen_US
dc.subjectDysfunctionen_US
dc.subjectDamageen_US
dc.subjectTimeen_US
dc.titleHyperbaric oxygen therapy prevents subarachnoid hemorrhage-induced apoptosis and impaired contractility of the rabbit bladderen_US
dc.typeArticleen_US

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