The Public Health Risks of β-Hemolytic Bacillus pumilus Bacteria Resistant to Gastrointestinal Conditions from Medicinal Plant

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dc.contributor.authorUgras, Serpil
dc.contributor.authorBahat, Dilsah
dc.date.accessioned2025-10-11T20:48:21Z
dc.date.available2025-10-11T20:48:21Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractIn numerous countries, the utilization of plants for both nutritional and therapeutic purposes is a common practice. However, the inadvertent use of these plants can pose risks due to their active molecules or microbiota. The traditional use of Herniaria glabra L. (H. glabra) plant in treating various diseases is well-known; however, its application in yogurt production raises concerns. In this study, Bacillus pumilus isolated from H. glabra was identified through 16s rRNA sequencing and MALDI-TOF MS (Matriks Assisted Lazer Desorption Ionization Time of Flight Massspectrometry). The bacterium's resistance under simulated gastrointestinal tract (GIT) conditions was assessed, followed by investigations into its aggregation ability, antibiotic resistance, hemolytic activity, and antagonistic potential through in vitro tests. The study revealed that B. pumilus exhibited 100% resistance to GIT conditions. Notably, the bacterium demonstrated strong autoaggregation (34.48%) and coaggregation abilities (49.82% for Escherichia coli, 49.13% for Listeria monocytogenes), signifying a potent aggregative potential. Sensitivity to most tested antibiotics was observed, while no antagonistic activity against tested bacteria was evident. Furthermore, the bacterium exhibited beta-hemolytic activity, indicative of potential virulence. The findings suggest that this resistant yet virulent bacterium, with its hemolytic activity, could disrupt the GIT balance, posing serious health risks. The study underscores the need for caution and awareness regarding the potential dangers posed by bacteria in plant microbiota in herbal therapies.en_US
dc.description.sponsorshipThe authors would like to thank Utku SARI for his help in obtaining the plant. Assistant Professor Didem AMBARLI from ODTU is thanked for his help with information about Henriari glabra.en_US
dc.identifier.doi10.1089/jmf.2024.0138
dc.identifier.endpage1113en_US
dc.identifier.issn1096-620X
dc.identifier.issn1557-7600
dc.identifier.issue11en_US
dc.identifier.pmid39172551en_US
dc.identifier.scopus2-s2.0-85201919386en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1106en_US
dc.identifier.urihttps://doi.org/10.1089/jmf.2024.0138
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21854
dc.identifier.volume27en_US
dc.identifier.wosWOS:001296187700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal of Medicinal Fooden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectaggregationen_US
dc.subjectantibioticsen_US
dc.subjectBacillus pumilusen_US
dc.subjectgastrointestinal systemen_US
dc.subjecthemolytic activityen_US
dc.subjectherbalen_US
dc.subjectHerniaria glabraen_US
dc.subjecttraditional treatmenten_US
dc.titleThe Public Health Risks of β-Hemolytic Bacillus pumilus Bacteria Resistant to Gastrointestinal Conditions from Medicinal Planten_US
dc.typeArticleen_US

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