Does Periosteal Graft Combined With Platelet-Rich Plasma Enhance the Healing of Bone Defect?

Basit Öğe Kaydı
dc.contributor.authorTürkseven, Arzu
dc.contributor.authorÖzçelik, Derya
dc.contributor.authorÇalış, Mert
dc.contributor.authorÇelik, Hakan Hamdi
dc.contributor.authorYılmaz, Fahri
dc.contributor.authorÖnbaş, Ömer
dc.contributor.authorToplu, Gaye
dc.date.accessioned2020-05-01T09:11:29Z
dc.date.available2020-05-01T09:11:29Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionVatansever, Alper/0000-0002-3632-1020en_US
dc.descriptionWOS: 000434304300097en_US
dc.descriptionPubMed: 29438203en_US
dc.description.abstractIntroduction:This study investigated the effect of periosteal graft + platelet-rich plasma (PRP) combination on facial bone defect healing. Methods: Five-millimeter critical sized defects in zygomatic arches of 12 adult New Zealand rabbits were created. Rabbits were randomly divided into 3 groups: First group (control group): bone defects of left zygomatic arches of 6 rabbits were wrapped with a silicone tube. Second group (periosteal graft group): bone defects of left zygomatic arches of 6 rabbits were wrapped with periosteal graft. Third group (experimental group): bone defects of right zygomatic arches of 12 rabbits were wrapped with periosteal graft-PRP combination. New bone formation was evaluated at 8th and 16th weeks. One rabbit was sacrificed at 8th week. Remaining 11 rabbits were imaged with 3-dimensional computed tomography (CT) at 16th week; then, zygomatic arches were removed for micro-CT and histologic examinations. Results: Three-dimensional CT analysis at 16th week revealed no significant difference between groups regarding new bone formation (P = 0.232). Micro-CT analysis of new regenerated bone at 16th week displayed significant differences between groups 1 and 3 regarding mean bone volume (BV, mm(3)) (P = 0.028) and mean bone mineral density (BMD, mm(2)) (P = 0.001). There was no difference between groups 2 and 3 or between groups 1 and 2, regarding BV or BMD. Histological Bone Regeneration Scorings at 16th week displayed significant difference between groups (P = 0.015). Negative correlation between 3-dimensional CT and histologic results (r = 0.120); positive correlations between BV/BMD values in micro-CT and histologic results (r = 0.524 and r = 0.456) were found. Conclusions: By enhancing bone formation capacity of periosteal grafts, periosteal graft-PRP combination provided bone formation having more volume and density comparing with silicone tube application.en_US
dc.description.sponsorshipDuzce University Scientific Research Foundation [2013.04.02.179]en_US
dc.description.sponsorshipThe authors acknowledge the support of Duzce University Scientific Research Foundation (Project No: 2013.04.02.179).en_US
dc.identifier.doi10.1097/SCS.0000000000004229en_US
dc.identifier.endpage1080en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1072en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000004229
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5618
dc.identifier.volume29en_US
dc.identifier.wosWOS:000434304300097en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone healingen_US
dc.subjectfractureen_US
dc.subjectgraften_US
dc.subjectperiosteumen_US
dc.subjectplatelet-rich plasmaen_US
dc.subjectrabbiten_US
dc.subjectzygomaen_US
dc.titleDoes Periosteal Graft Combined With Platelet-Rich Plasma Enhance the Healing of Bone Defect?en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5618.pdf
Boyut:
621.63 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu