Serum Sistatin-C düzeyleri Diyastolik Kalp Yetmezliğinde Öngördürücü Olabilir
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Dosyalar
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Duzce Univ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Diyastolik kalp yetmezliği; sistolik kalp yetmezliği gibi değerlendirilirken aslında
bunların birbirinden ayrı patofizyolojik mekanizmalarla ilerlediği bilinmektedir.
Çalışmamızda serum Sistatin C düzeyi ve diyastolik fonksiyon bozukluğu arasındaki ilişkiyi
incelemeyi hedefledik.
Gereç ve Yöntem: Mayıs 2010 ve Eylül 2010 tarihleri arasında Düzce Üniversitesi Tıp
Fakültesi Hastanesi Kardiyoloji polikliniğine başvuranlar kabul edildi. Hastaların diyastolik
parametreleri değerlendirildi ve serum Sistatin C düzeyleri çalışıldı. Hastalar diyastolik
fonksiyonlarına göre normal, grade 1, grade 2 olarak üç gruba ayrıldı ve serum Sistain C
düzeyi ile bu gruplar arasında ilişki araştırıldı.
Bulgular: Grade 1 ve grade 2 diyastolik disfonksiyonu olan hastalar ile diyastolik fonksiyon
bozukluğu olmayanlar serum Sistatin C seviyelerine göre karşılaştırıldı. Diyastolik
disfonksiyon olan gruplarda Sistatin C düzeyinde anlamlı düzeyde artış olduğu gösterildi
(grade 1:p<0,0001, grade 2: P<0,004). Serum sistatin C seviyeleri için Reciever operating
eğrisi (ROC) , serum sistatin C > 0,997 ng / ml seviyesinde, diyastolik disfonksiyonu % 80
özgüllük ve% 78.95 duyarlılık ile tanımlayabildi.
Sonuç: Serum sistain C düzeyi diyastolik disfonksiyonun erken tespitinde ve takibinde
faydalı olabilir.
Objective: Diastolic heart failure was accepted as systolic heart failure but nowadays it is known they have distinct pathophysiological mechanism. We aimed to investigate the association between diastolic dysfunction and serum cystatin C concentrations. Methods: Patients admitted to cardiology clinic of Duzce University School of Medicine from May 2010 to September 2010 were included. Serum cystatin C concentrations and diastolic echocardiography parameters were studied. Diastolic echocardiographic parameters were measured with 2D echocardiography, TDI (Tissue Doppler imaging) and PW (Pulsed Wave) Doppler. Patients were categorized into three groups; grade 1, grade 2, grade 3 according to their diastolic functions. Serum cystatin C levels were compared among the groups. Results: Patients with diastolic dysfunction were compared with controls (patients without diastolic dysfunction) according to their serum cystatin C levels. A statistically significant increase in serum cystatin C level was observed in patients with diastolic dysfunction (grade1:p<0,0001, grade 2:p<0,004). The receiver operating characteristic curve for serum cystatin C levels revealed a level > 0,997 ng/ml could identify diastolic dysfunction with a specificity of % 80 and a sensitivity of %78.95. Conclusion: Serum Cystatin C levels may be useful in the early detection and monitoring of diastolic dysfunction.
Objective: Diastolic heart failure was accepted as systolic heart failure but nowadays it is known they have distinct pathophysiological mechanism. We aimed to investigate the association between diastolic dysfunction and serum cystatin C concentrations. Methods: Patients admitted to cardiology clinic of Duzce University School of Medicine from May 2010 to September 2010 were included. Serum cystatin C concentrations and diastolic echocardiography parameters were studied. Diastolic echocardiographic parameters were measured with 2D echocardiography, TDI (Tissue Doppler imaging) and PW (Pulsed Wave) Doppler. Patients were categorized into three groups; grade 1, grade 2, grade 3 according to their diastolic functions. Serum cystatin C levels were compared among the groups. Results: Patients with diastolic dysfunction were compared with controls (patients without diastolic dysfunction) according to their serum cystatin C levels. A statistically significant increase in serum cystatin C level was observed in patients with diastolic dysfunction (grade1:p<0,0001, grade 2:p<0,004). The receiver operating characteristic curve for serum cystatin C levels revealed a level > 0,997 ng/ml could identify diastolic dysfunction with a specificity of % 80 and a sensitivity of %78.95. Conclusion: Serum Cystatin C levels may be useful in the early detection and monitoring of diastolic dysfunction.
Açıklama
WOS: 000441304600011
Anahtar Kelimeler
Diastolic Heart Failure, Diastolic Dysfunction, Cystatin C, Echocardiography
Kaynak
Konuralp Tip Dergisi
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
10
Sayı
2
