In Vitro Genotoxic and Cytotoxic Evaluation of Phenoxyethanol in Human Lymphocytes: A Commonly Used Preservative in Cosmetics

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dc.contributor.authorKara, Ikbal Hesna
dc.contributor.authorYildiz, Esra
dc.contributor.authorMeredova, Guncha
dc.contributor.authorAksoy, Hueseyin
dc.date.accessioned2025-10-11T20:48:49Z
dc.date.available2025-10-11T20:48:49Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPhenoxyethanol is widely used as a preservative in many cosmetic products and is considered to be safe. although there are some toxicity studies on phenoxyethanol, no detailed research evaluating its genotoxicity in human lymphocytes is available in the literature. This study aims to assess phenoxyethanol ' s cytotoxic and genotoxic profiles in human peripheral blood lymphocytes. For evaluation of genotoxic and cytotoxic effects of phenoxyethanol, chromosomal aberration (CA) and micronucleus (MN) tests were applied In both tests, lymphocyte cultures were treated with three concentrations (50, 25, 12.5 mu g/mL) of phenoxyethanol and control groups (solvent, positive and negative controls). When examining the results of the chromosomal aberration test (CA) and the micronucleus test (MN), no significant differences were observed between the solvent control group and the application concentrations in either test. For the evaluation of cytotoxicity, mitotic index results showed a significant decrease at higher doses (50 and 25 mu g/mL) compared to the solvent control. In conclusion, phenoxyethanol did not exhibit genotoxic effects (clastogenic and aneugenic) on human peripheral lymphocyte cells at the applied doses, although it did show a slight cytotoxic effect.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK) [1919B012304729]en_US
dc.description.sponsorshipThis study was financially supported by the Scientific and Technological Research Council of Turkiye (TUBITAK, Project number: 1919B012304729).en_US
dc.identifier.doi10.1002/jbt.70417
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue8en_US
dc.identifier.pmid40741871en_US
dc.identifier.scopus2-s2.0-105012354609en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.70417
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22122
dc.identifier.volume39en_US
dc.identifier.wosWOS:001542408900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemicaland Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectchromosome aberrationen_US
dc.subjectcytotoxicityen_US
dc.subjectgenotoxicityen_US
dc.subjectmicronucleusen_US
dc.subjectphenoxyethanolen_US
dc.titleIn Vitro Genotoxic and Cytotoxic Evaluation of Phenoxyethanol in Human Lymphocytes: A Commonly Used Preservative in Cosmeticsen_US
dc.typeArticleen_US

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