Bilateral Superior Cervical Ganglionectomy and Melatonin Levels in Rat Subarachnoid Hemorrhage Model: Simple Precautions May Preserve Melatonin Levels

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dc.authorscopusid57193240432
dc.authorscopusid15220645600
dc.authorscopusid56857485400
dc.contributor.authorKılıç, Güven
dc.contributor.authorKayabaş, M.
dc.contributor.authorCancan, S.E.
dc.date.accessioned2023-07-26T11:55:07Z
dc.date.available2023-07-26T11:55:07Z
dc.date.issued2021
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractAim: Subarachnoid hemorrhage (SAH) is a serious disease, and it is thought that melatonin may have positive effects after SAH. Bilateral resection or blockage of superior cervical ganglions has constant effects on melatonin levels. Animal models with bilateral superior cervical ganglionectomy (SCG) show the role of superior cervical ganglion on melatonin and give clues about simple precautions which may help to prevent unfavorable outcomes in SAH patients. The aim of this study is to examine how melatonin levels change in SAH and SCG models. Material and Methods: Forty-two Sprague Dawley male rats weighing 200-250 g were used in the study and randomly divided into six groups. Arterial blood samples were collected 24 hours after the procedure in all groups. Serum melatonin levels of the groups were studied. Results: A significant difference in blood melatonin levels was observed between SAH and SCG groups, and against the control group. There was no significant difference between the melatonin levels in SCG group and SAH+SCG group (p=0.983). The mean blood melatonin level of the SAH group was higher than the SCG (p<0.001), SAH+SCG (p<0.001) and control groups (p=0.001). The mean blood melatonin levels of SAH+SCG and SCG groups were lower than the mean blood melatonin levels of the other groups and also the SAH group (p<0.001). Conclusion: Bilateral SCG significantly inhibited the abrupt increase of serum melatonin levels after SAH model in rats. Future studies aiming to address melatonin’s complex outcomes should take into account that minor exogenous factors may affect serum melatonin levels. © 2021, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.1012828
dc.identifier.endpage317en_US
dc.identifier.issn1307-671X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85125315337en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage313en_US
dc.identifier.trdizinid495754en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1012828
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/495754
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13001
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKılıç, Güven
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectMelatoninen_US
dc.subjectSubarachnoid hemorrhageen_US
dc.subjectSuperior cervical ganglionen_US
dc.subjectmelatoninen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectarterial blooden_US
dc.subjectArticleen_US
dc.subjectblood samplingen_US
dc.subjectcerebrospinal fluiden_US
dc.subjectcontrolled studyen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectgeneral anesthesiaen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectoutcome assessmenten_US
dc.subjectraten_US
dc.subjectsham procedureen_US
dc.subjectsubarachnoid hemorrhageen_US
dc.subjectsuperior cervical ganglionen_US
dc.subjectsuperior cervical ganglionectomyen_US
dc.titleBilateral Superior Cervical Ganglionectomy and Melatonin Levels in Rat Subarachnoid Hemorrhage Model: Simple Precautions May Preserve Melatonin Levelsen_US
dc.title.alternativeSıçan Subaraknoid Kanama Modelinde Bilateral Superior Servikal Ganglionektomi ve Melatonin Seviyeleri: Basit Önlemler Melatonin Düzeylerini Koruyabiliren_US
dc.typeArticleen_US

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