Exploring the Inflammatory Basis of Endometrial Polyps: Clinical Implications of Hematological Biomarkers in a Retrospective Study

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dc.authoridKeyif, Betul/0000-0002-7472-551X;
dc.contributor.authorKeyif, Betul
dc.contributor.authorYavuzcan, Ali
dc.contributor.authorYurtcu, Engin
dc.contributor.authorBasbug, Alper
dc.contributor.authorDuzenli, Fatmanur
dc.contributor.authorKeyif, Elif
dc.contributor.authorGoynumer, Fikret Gokhan
dc.date.accessioned2025-10-11T20:47:47Z
dc.date.available2025-10-11T20:47:47Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground/Objectives: Endometrial polyps (EPs) are common benign endometrial lesions often linked to abnormal uterine bleeding and infertility. While hormonal factors play a key role in their development, recent studies suggest a potential inflammatory component. This retrospective study aimed to assess systemic inflammatory markers, including mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in EP patients. Methods: A total of 180 patients were classified into three groups: EP (n = 60), chronic endometritis (n = 60), and control (n = 60). Preoperative hematological parameters were retrieved from medical records. Group comparisons were performed using one-way ANOVA, with Tukey's post hoc test applied when significant. Multinomial logistic regression was used to identify independent predictors of EPs. Results: MPV and PLR were significantly higher in the EP group compared to other groups (p = 0.014 and p = 0.015, respectively), while NLR differences were not statistically significant (p = 0.086). Logistic regression identified MPV (p = 0.004) and PLR (p = 0.045) as independent predictors of EPs. Conclusions: These findings suggest that systemic inflammation may contribute to EP development, with MPV and PLR serving as potential inflammatory biomarkers. Further prospective studies with histopathological validation are needed to clarify the role of inflammation in EP pathogenesis.en_US
dc.identifier.doi10.3390/jcm14082754
dc.identifier.issn2077-0383
dc.identifier.issue8en_US
dc.identifier.pmid40283584en_US
dc.identifier.scopus2-s2.0-105003395776en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm14082754
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21556
dc.identifier.volume14en_US
dc.identifier.wosWOS:001475520100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectchronic endometritisen_US
dc.subjectendometrial polypen_US
dc.subjecthematological biomarkersen_US
dc.subjectinflammationen_US
dc.subjectmean platelet volumeen_US
dc.subjectneutrophil-to-lymphocyte ratioen_US
dc.subjectplatelet-to-lymphocyte ratioen_US
dc.titleExploring the Inflammatory Basis of Endometrial Polyps: Clinical Implications of Hematological Biomarkers in a Retrospective Studyen_US
dc.typeArticleen_US

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