Delayed habituation in Behcet's disease

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dc.contributor.authorGültürk, Sefa
dc.contributor.authorAkyol, Melih
dc.contributor.authorKeçeci, Hulusi
dc.contributor.authorÖzçelik, Sedat
dc.contributor.authorÇınar, Ziynet
dc.contributor.authorDemirkazık, Ayşe
dc.date.accessioned2020-05-01T09:11:17Z
dc.date.available2020-05-01T09:11:17Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000254671200006en_US
dc.descriptionPubMed: 18310833en_US
dc.description.abstractBackground: The autonomic nervous system in Behcet's patients may be affected due to various reasons. This entity may be detected with the measurement of the electrodermal activities, heart rate variability and pupillometric methods. Habituation is one of the implicit forms of learning and memory and the loss of habituation can reveal pathological changes in the synaptic regions. Aim: To determine whether there is a functional decrease in the synaptic effectiveness (habituation) of the pathways to sympathetic neurons that had been repeatedly activated in Behcet's. Materials and Methods: Twelve patients with Behcet's disease and 12 healthy controls were included in the study. Sympathetic skin potential (SSP) records were taken at normal room temperature in a quiet place within a Faraday cage. Sixteen square wave single shock impulses (duration: 1200 mu s, strength: 5 mA) were applied on each case. Results: After the 1(st) stimulus, the SSP amplitudes were lower in the patients compared to the controls (P 0.001, t value = 7.69). There was no significant differences among the SSP amplitudes after the 13(th) impulse in the patients (P>0.05). Whereas there was no significant differences among the SSP amplitudes after the 9(th) impulse in the controls (P>0.05). The habituation rate of the SSP after consecutive impulses was slowest in the patients compared to controls (P<0.001, t value = 12.39). Conclusions: There is a delayed habituation in Behcet's disease and that may due to pathologic changes with vasculitis through their peripheral nerves.en_US
dc.identifier.doi10.4103/0028-3886.39308en_US
dc.identifier.endpage30en_US
dc.identifier.issn0028-3886
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.4103/0028-3886.39308
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5470
dc.identifier.volume56en_US
dc.identifier.wosWOS:000254671200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNeurol Soc Indiaen_US
dc.relation.ispartofNeurology Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautonomic nervous systemen_US
dc.subjectBehcet's disease habituationen_US
dc.subjectsympathetic skin potentialsen_US
dc.titleDelayed habituation in Behcet's diseaseen_US
dc.typeArticleen_US

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