Beyond BMI: Ultrasound-Detected Visceral Adiposity as a Predictor of Early Cardiometabolic Dysfunction in Youth with Type 1 Diabetes

Basit Öğe Kaydı
dc.contributor.authorOzde, Sukriye
dc.contributor.authorAkture, Gulsah
dc.contributor.authorOzel, Mehmet Ali
dc.contributor.authorYavuzyilmaz, Fatma
dc.contributor.authorOzde, Cem
dc.contributor.authorKayapinar, Osman
dc.contributor.authorArslanoglu, Ilknur
dc.date.accessioned2026-07-01T11:39:21Z
dc.date.available2026-07-01T11:39:21Z
dc.date.issued2026
dc.departmentDüzce Üniversitesi
dc.description.abstractHighlights What are the main findings? center dot Perirenal and epicardial adipose tissue thicknesses are significantly increased in children and adolescents with type 1 diabetes mellitus, independent of overall body mass index. center dot Higher visceral adipose tissue thickness is associated with reduced insulin sensitivity, systemic inflammation, and increased carotid intima-media thickness, indicating early subclinical atherosclerosis. What are the implications of the main findings? center dot Ultrasonographic assessment of perirenal and epicardial fat provides a simple, noninvasive tool for early cardiometabolic risk stratification in pediatric type 1 diabetes. center dot Visceral adiposity-based imaging markers may help identify high-risk children who could benefit from earlier preventive cardiovascular interventions beyond glycemic control alone.Highlights What are the main findings? center dot Perirenal and epicardial adipose tissue thicknesses are significantly increased in children and adolescents with type 1 diabetes mellitus, independent of overall body mass index. center dot Higher visceral adipose tissue thickness is associated with reduced insulin sensitivity, systemic inflammation, and increased carotid intima-media thickness, indicating early subclinical atherosclerosis. What are the implications of the main findings? center dot Ultrasonographic assessment of perirenal and epicardial fat provides a simple, noninvasive tool for early cardiometabolic risk stratification in pediatric type 1 diabetes. center dot Visceral adiposity-based imaging markers may help identify high-risk children who could benefit from earlier preventive cardiovascular interventions beyond glycemic control alone.Abstract Background: Visceral adiposity has emerged as a clinically relevant determinant of early cardiometabolic dysfunction in pediatric type 1 diabetes mellitus (T1DM), yet its assessment remains underutilized in routine practice. This study evaluated ultrasonographically measured epicardial adipose tissue thickness (EATT) and perirenal adipose tissue thickness (PrATT) as markers of metabolic risk, insulin sensitivity, and subclinical atherosclerosis in children and adolescents with T1DM. Methods: This cross-sectional study included 150 participants with T1DM and 152 age- and sex-matched healthy controls. Anthropometric data, biochemical parameters, hepatic steatosis grade, and insulin sensitivity indices (eGDR) were collected. EATT and PrATT were measured via standardized echocardiographic and abdominal ultrasonographic protocols. Carotid intima-media thickness (cIMT) was assessed as an indicator of subclinical atherosclerosis. Correlation and multivariable logistic regression analyses were performed to identify independent predictors of T1DM status and cardiometabolic risk. Results: Children with T1DM exhibited significantly higher PrATT and EATT values compared with controls (both p < 0.05). All eGDR indices were markedly lower in the T1DM group, reflecting reduced insulin sensitivity. PrATT and EATT showed strong or moderate correlations with hsCRP, hepatic steatosis, atherogenic index of plasma, and multiple anthropometric markers. Both visceral fat depots were positively associated with cIMT. Logistic regression identified PrATT, EATT, hsCRP, cIMT, and eGDR-BMI as independent predictors of case status. Subgroup analyses demonstrated more pronounced visceral adiposity and metabolic impairment among participants with BMI >= 85th percentile. Conclusions: Ultrasonographically measured PrATT and EATT provide valuable insight into early cardiometabolic risk in youth with T1DM, independent of BMI. Their associations with insulin resistance, inflammation, and subclinical atherosclerosis highlight their potential utility as accessible markers for early risk stratification in pediatric diabetes. Routine incorporation of visceral fat assessment may support earlier identification of high-risk individuals and more targeted preventive strategies.
dc.identifier.doi10.3390/children13010124
dc.identifier.issn2227-9067
dc.identifier.issue1
dc.identifier.orcid0000-0002-8389-5174
dc.identifier.pmid41597132
dc.identifier.scopus2-s2.0-105029135377
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/children13010124
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23252
dc.identifier.volume13
dc.identifier.wosWOS:001671967500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofChildren-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260623
dc.subject[Keyword Not Available]
dc.titleBeyond BMI: Ultrasound-Detected Visceral Adiposity as a Predictor of Early Cardiometabolic Dysfunction in Youth with Type 1 Diabetes
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu