Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow

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dc.contributor.authorYücel, Habil
dc.contributor.authorÖzaydın, Mehmet
dc.contributor.authorDoğan, Abdullah
dc.contributor.authorErdoğan, Doğan
dc.contributor.authorTürker, Yasin
dc.contributor.authorCeyhan, Betül Mermi
dc.contributor.authorSütçü, Recep
dc.date.accessioned2020-04-30T23:21:01Z
dc.date.available2020-04-30T23:21:01Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000308941400010en_US
dc.descriptionPubMed: 22950626en_US
dc.description.abstractObjectives. Slow coronary flow (SCF) is slow progression of contrast agent in the coronary arteries in the absence of stenosis in epicardial coronary vessels. Endothelial dysfunction and diffuse atherosclerosis have been proposed for the etiology of SCF. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, levels are associated with an increased risk of endothelial dysfunction and atherosclerosis. ADMA levels may be increased by homocysteine. The aim of this study was to evaluate the relationship between ADMA, nitric oxide and homocysteine in patients with SCF. Methods. The study group consisted of 50 patients with SCF. An age-and gender-matched control group was composed of 30 patients with normal coronary arteries and normal coronary flow on coronary angiography. We measured ADMA, nitric oxide and homocysteine plasma concentrations in all patients. Results. Plasma nitric oxide concentrations were significantly lower in the SCF group than in the control group (11.4 +/- 6, 16.1 +/- 9, p = 0.02). Plasma ADMA concentrations (0.9 +/- 0.3, 0.7 +/- 0.3, p = 0.01) and plasma homocysteine concentrations (12.4 +/- 5, 9.8 +/- 2, p = 0.03) were significantly higher in the SCF group than control group. The mean TIMI frame count (TFC) was significantly correlated with plasma ADMA (r = 0.26, p = 0.02) and homocysteine (r = 0.28, p = 0.02) concentrations, but not with nitric oxide concentrations (r = -0.18, p = 0.13). In linear regression analysis, plasma ADMA concentrations (beta = 4.6, p = 0.005) and homocysteine concentrations (beta = 0.2, p = 0.03) were independently and positively associated with mean TFC. Conclusion. Our results suggest that plasma concentrations of ADMA and homocysteine are increased in SCF and also that these are independent predictors of SCF.en_US
dc.identifier.doi10.3109/00365513.2012.699637en_US
dc.identifier.endpage500en_US
dc.identifier.issn0036-5513
dc.identifier.issn1502-7686
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage495en_US
dc.identifier.urihttps://doi.org/10.3109/00365513.2012.699637
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4122
dc.identifier.volume72en_US
dc.identifier.wosWOS:000308941400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofScandinavian Journal Of Clinical & Laboratory Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric dimethylarginineen_US
dc.subjecthomocysteineen_US
dc.subjectnitric oxideen_US
dc.subjectslow coronary flowen_US
dc.titlePlasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flowen_US
dc.typeArticleen_US

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