Alterations in neuroendocrine axes in brain-dead patients

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dc.authoridAkbas, Turkay/0000-0002-2150-6866en_US
dc.authorscopusid22133297600en_US
dc.authorscopusid57220554060en_US
dc.authorwosidAkbas, Turkay/G-4609-2016en_US
dc.contributor.authorAkbas, Turkay
dc.contributor.authorOzturk, Ayhan
dc.date.accessioned2024-08-23T16:04:58Z
dc.date.available2024-08-23T16:04:58Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPurposeTo identify changes in anterior pituitary gland hormone levels in brain-dead patients and alterations in free triiodothyronine (fT3), free thyroxine, cortisol, testosterone, and estradiol levels.MethodsTen postmenopausal women and 22 men with brain death (BD) were included. The first blood sample for determination of hormones (pre-BD) was collected when the clinician observed the first signs of BD. The second blood sample (BD day) was drawn after BD certification.ResultsFemale patients exhibited lower follicle-stimulating hormone and prolactin levels pre-BD and luteinizing hormone, follicle-stimulating hormone, and prolactin levels on BD day than the age-matched controls. Male patients' sex hormone levels were similar to those of the age-matched controls, except for testosterone levels, which were low in both consecutive measurements. All gonadotropins and prolactin levels were above the tests' lower detection limits (LDLs), except for one male patient with gonadotropin levels below the LDLs of the tests. Estradiol levels in both sexes ranged from normal to elevated. FT3 levels were significantly decreased in the two measurements. Thyroid-stimulating hormone (TSH) levels were low in eight patients and all low TSH levels were above the test's LDL. The remaining patients had normal or elevated TSH levels. The median adrenocorticotropic hormone (ACTH) and cortisol levels were within normal limits. All cortisol and ACTH levels were above the tests' LDLs, except for one patient with ACTH levels below the LDL in both measurements.ConclusionThis study supports the hypothesis that the anterior pituitary gland continues to function in the brain-dead state.en_US
dc.identifier.doi10.1007/s42000-023-00489-9
dc.identifier.endpage546en_US
dc.identifier.issn1109-3099
dc.identifier.issn2520-8721
dc.identifier.issue4en_US
dc.identifier.pmid37736855en_US
dc.identifier.scopus2-s2.0-85171773768en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://doi.org/10.1007/s42000-023-00489-9
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14431
dc.identifier.volume22en_US
dc.identifier.wosWOS:001069938500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofHormones-International Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain deathen_US
dc.subjectCortisolen_US
dc.subjectPituitary hormonesen_US
dc.subjectSex hormonesen_US
dc.subjectThyroid hormonesen_US
dc.subjectTumor-Necrosis-Factoren_US
dc.subjectPituitary-Functionen_US
dc.subjectSerumen_US
dc.subjectEstrogenen_US
dc.subjectIllnessen_US
dc.subjectDonorsen_US
dc.subjectAxisen_US
dc.titleAlterations in neuroendocrine axes in brain-dead patientsen_US
dc.typeArticleen_US

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