Evaluation of Patients with Fibrotic Interstitial Lung Disease: Preliminary results from the Turk-UIP Study

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dc.authoridNiksarlioglu, Elif Yelda/0000-0002-6119-6540
dc.authorwosidNiksarlioglu, Elif Yelda/X-7048-2019
dc.contributor.authorBenan, Musellim
dc.contributor.authorNesrin, Mogulkoc
dc.contributor.authorOguz, Uzun
dc.contributor.authorFatma, Tokgoz Akyil
dc.contributor.authorHaluk, Turktas
dc.contributor.authorOzlem, Ozdemir Kumbasar
dc.contributor.authorNihat, Annakkaya Ali
dc.date.accessioned2021-12-01T18:51:17Z
dc.date.available2021-12-01T18:51:17Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractOBJECTIVE: Differential diagnosis of idiopathic pulmonary fibrosis (IPF) is important among fibrotic interstitial lung diseases (ILD). This study aimed to evaluate the rate of IPF in patients with fibrotic ILD and to determine the clinical-laboratory features of patients with and without IPF that would provide the differential diagnosis of IPF. MATERIAL AND METHODS: The study included the patients with the usual interstitial pneumonia (UIP) pattern or possible UIP pattern on thorax high-resolution computed tomography, and/or UIP pattern, probable UIP or possible UIP pattern at lung biopsy according to the 2011 ATS/ERSARS/ALAT guidelines. Demographics and clinical and radiological data of the patients were recorded. All data recorded by researchers was evaluated by radiology and the clinical decision board. RESULTS: A total of 336 patients (253 men, 83 women, age 65.8 +/- 9.0 years) were evaluated. Of the patients with sufficient data for diag-nosis (n=300), the diagnosis was IPF in 121 (40.3%), unclassified idiopathic interstitial pneumonia in 50 (16.7%), combined pulmonary fibrosis and emphysema (CPFE) in 40 (13.3%), and lung involvement of connective tissue disease (CTD) in 16 (5.3%). When 29 patients with definite IPF features were added to the patients with CPFE, the total number of IPF patients reached 150 (50%). Rate of male sex (p<0.001), smoking history (p<0.001), and the presence of clubbing (p=0.001) were significantly high in patients with IPE None of the women <50 years and none of the men <50 years of age without a smoking history were diagnosed with IPE Presence of at least 1 of the symptoms suggestive of CTD, erythrocyte sedimentation rate (ESR), and antinuclear antibody (FANA) positivity rates were significantly higher in the non-IPF group (p<0.001, p=0.029, p=0.009, respectively). CONCLUSION: The rate of IPF among patients with fibrotic ILD was 50%. In the differential diagnosis of IPF, sex, smoking habits, and the presence of clubbing are important. The presence of symptoms related to CTD, ESR elevation, and EANA positivity reduce the likelihood of IPF.en_US
dc.description.sponsorshipcompany of Rocheen_US
dc.description.sponsorshipThis research received unconditional financial support from the company of Roche.en_US
dc.identifier.doi10.5152/TurkThoracJ.2021.20028
dc.identifier.endpage109en_US
dc.identifier.issn2149-2530
dc.identifier.issue2en_US
dc.identifier.pmid33871332en_US
dc.identifier.scopus2-s2.0-85103621219en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage102en_US
dc.identifier.urihttps://doi.org/10.5152/TurkThoracJ.2021.20028
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10991
dc.identifier.volume22en_US
dc.identifier.wosWOS:000659040700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Thoracic Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFibrotic interstitial lung diseasesen_US
dc.subjectidiopathic pulmonary fibrosisen_US
dc.subjectusual interstitial pneumoniaen_US
dc.subjectIdiopathic Pulmonary-Fibrosisen_US
dc.subjectClinical-Practiceen_US
dc.subjectDiagnosisen_US
dc.subjectEpidemiologyen_US
dc.titleEvaluation of Patients with Fibrotic Interstitial Lung Disease: Preliminary results from the Turk-UIP Studyen_US
dc.typeArticleen_US

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