In vivo evaluation of teicoplanin- and calcium sulfate-loaded PMMA bone cement in preventing implant-related osteomyelitis in rats

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dc.contributor.authorTüzüner, Tolga
dc.contributor.authorŞencan, İrfan
dc.contributor.authorÖzdemir, Davut
dc.contributor.authorAlper, Murat
dc.contributor.authorDuman, S.
dc.contributor.authorYavuz, Tevfik
dc.contributor.authorYıldırım, Mustafa
dc.date.accessioned2020-04-30T23:18:28Z
dc.date.available2020-04-30T23:18:28Z
dc.date.issued2006
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionalper, murat/0000-0001-7069-0623en_US
dc.descriptionWOS: 000243185500008en_US
dc.descriptionPubMed: 17267341en_US
dc.description.abstractThe objective of this study was to evaluate the efficacy of teicoplanin- and calcium sulphate-loaded polymethylmethacrylate (PMMA) bone cements in preventing experimental implant-related osteomyelitis in rats. Four groups of antibiotic-loaded rods were prepared and were implanted into the lateral condylus of the rat femur after inoculation of Staphylococcus aureus. The effectiveness of these were assessed microbiologically, radiographically, and histopathologically. Radiographic evaluation revealed a significant reduction of periostal reaction and osteolysis in rats that received calcium sulphate- and teicoplanin-loaded rods. Histopathological evaluation confirmed these results. Acute infection and bone necrosis were found to be significantly lower in rats that had received calcium sulphate- and teicoplanin-loaded rods. The addition of calcium sulfate to teicoplanin-loaded PMMA bone cement appeared satisfactory as an antibiotic-carrying system for prophylaxis of experimental implant-related osteomyelitis, but further investigations are needed to reach definitive statements for clinical applications.en_US
dc.identifier.doi10.1179/joc.2006.18.6.628en_US
dc.identifier.endpage633en_US
dc.identifier.issn1120-009X
dc.identifier.issue6en_US
dc.identifier.startpage628en_US
dc.identifier.urihttps://doi.org/10.1179/joc.2006.18.6.628
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3332
dc.identifier.volume18en_US
dc.identifier.wosWOS:000243185500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEsift Srlen_US
dc.relation.ispartofJournal Of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcalcium sulfateen_US
dc.subjectteicoplaninen_US
dc.subjectbone cementen_US
dc.subjectosteomyelitisen_US
dc.titleIn vivo evaluation of teicoplanin- and calcium sulfate-loaded PMMA bone cement in preventing implant-related osteomyelitis in ratsen_US
dc.typeArticleen_US

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