Effect of the Combination of Exercise and Metformin on Osteocalcin, Insülin, Interleukin-6, Glucose Levels, and Body Weights in Rats

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dc.authorscopusid57188813441en_US
dc.authorscopusid28367543600en_US
dc.authorscopusid59195623200en_US
dc.authorscopusid56155004800en_US
dc.contributor.authorBeyazcicek, O.
dc.contributor.authorBeyazcicek, E.
dc.contributor.authorKubur, U. B.
dc.contributor.authorGok, A.
dc.date.accessioned2024-08-23T16:03:28Z
dc.date.available2024-08-23T16:03:28Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: Exercise or exercise capacity is a vital physiological function. It is known that certain cytokines support muscle function during exercise and, as a result, increase exercise capacity. Aims:In this study, the effect of metformin administered in combination with exercise on osteocalcin (OCN), insulin, and interleukin-6 (IL-6) levels in rats was investigated. Methods: Forty-two male Wistar rats were used in this study. The animals were randomly divided into six groups: control (CONT), only exercise (EXE), metformin_100 mg/kg (Met100), metformin_200 mg/kg (Met200), metformin_100 mg/kg+exercise (Met100+EXE), and metformin_200 mg/kg+exercise (Met200+EXE). A 10-week intervention was conducted, excluding exercise training. During the experiment, the groups receiving metformin application (100 or 200 mg/kg) were administered with metformin. At the end of the study, serum samples were collected from the rats to determine the levels of osteocalcin, insulin, and IL-6 using the enzyme-linked immunosorbent assay method. In addition, glucose levels and body weights were evaluated. GraphPad Prism was used for the analyses. Results: The OCN and insulin levels of the Met100+EXE and Met200+EXE groups were found to be higher compared to the CONT, Met100, and Met200 groups (P < 0.05). The IL-6 level of the EXE group was determined to be higher than that of the CONT, Met100, and Met200 groups (P < 0.01). It was observed that both exercise and the individual or combined application of metformin resulted in lower blood glucose levels compared to the CONT group. The mean body weight of the EXE group was higher than that of the other groups. Conclusion: The combined application of metformin and exercise has increased osteocalcin and insulin levels compared to metformin application alone.en_US
dc.description.sponsorshipDuzce University [2021.04.01.1212]en_US
dc.description.sponsorshipThis is supported by Duzce University Research Fund Project Number: 2021.04.01.1212.en_US
dc.identifier.doi10.4103/njcp.njcp_884_23
dc.identifier.endpage773en_US
dc.identifier.issn1119-3077
dc.identifier.issn2229-7731
dc.identifier.issue6en_US
dc.identifier.pmid38943302en_US
dc.identifier.scopus2-s2.0-85197107860en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage766en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_884_23
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13771
dc.identifier.volume27en_US
dc.identifier.wosWOS:001258543900012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExerciseen_US
dc.subjectinsulinen_US
dc.subjectinterleukin-6en_US
dc.subjectmetforminen_US
dc.subjectosteocalcinen_US
dc.subjectGene-Expressionen_US
dc.subjectBeta-Cellen_US
dc.subjectInsulinen_US
dc.subjectSufficienten_US
dc.subjectMetabolismen_US
dc.subjectMuscleen_US
dc.titleEffect of the Combination of Exercise and Metformin on Osteocalcin, Insülin, Interleukin-6, Glucose Levels, and Body Weights in Ratsen_US
dc.typeArticleen_US

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