Effects of Urtica dioica on hepatic ischemia-reperfusion injury in rats

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dc.contributor.authorKandiş, Hayati
dc.contributor.authorKarapolat, Sami
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorSarıtaş, Ayhan
dc.contributor.authorGezer, Suat
dc.contributor.authorMemişoğulları, Ramazan
dc.date.accessioned2020-05-01T09:12:06Z
dc.date.available2020-05-01T09:12:06Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionSaritas, Ayhan/0000-0002-4302-1093; Saritas, Ayhan/0000-0002-4302-1093; Kandis, Hayati/0000-0001-9151-6050en_US
dc.descriptionWOS: 000288493400021en_US
dc.descriptionPubMed: 21340227en_US
dc.description.abstractOBJECTIVES: To evaluate the effects of Urtica dioica on hepatic ischemia-reperfusion injury. METHODS: Thirty adult male Wistar albino rats were divided into three groups: sham group (group 1), control group (group 2), and Urtica dioica group (group 3). All the rats were exposed to hepatic ischemia for 60 min, followed by 60 min of reperfusion. In group 2, a total of 2 ml/kg 0.9% saline solution was given intraperitoneally. In group 3, a total of 2 ml/kg Urtica dioica was given intraperitoneally. At the end of the procedure, liver tissue and blood samples were taken from all rats. Serum aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, ceruloplasmin, catalase, paraoxonase, arylesterase, and lipid hydroperoxide levels were measured. Liver tissue histopathologies were also evaluated by light microscopy. RESULTS: Serum aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were significantly higher in group 2 than in group 1, and significantly lower in group 3 than in group 2. Also, group 2 had higher serum lipid hydroperoxides and ceruloplasmin levels but lower catalase, paraoxonase, and arylesterase levels than group 1. In group 3, serum lipid hydroperoxides and ceruloplasmin levels were significantly lower, and catalase, paraoxonase, and arylesterase levels were higher than those in group 2. Histopathological examination showed that liver tissue damage was significantly decreased in group 3 compared with group 2. CONCLUSIONS: Urtica dioica has a protective effect on the liver in hepatic ischemia-reperfusion-injured rats.en_US
dc.identifier.doi10.1590/S1807-59322010001200021en_US
dc.identifier.endpage1361en_US
dc.identifier.issn1807-5932
dc.identifier.issue12en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1357en_US
dc.identifier.urihttps://doi.org/10.1590/S1807-59322010001200021
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5877
dc.identifier.volume65en_US
dc.identifier.wosWOS:000288493400021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHospital Clinicas, Univ Sao Pauloen_US
dc.relation.ispartofClinicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiveren_US
dc.subjectSurgeryen_US
dc.subjectIschemiaen_US
dc.subjectReperfusion injuryen_US
dc.subjectUrtica dioicaen_US
dc.titleEffects of Urtica dioica on hepatic ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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