High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line

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dc.authoridkar, fatih/0000-0001-8356-9806
dc.authoridKacar, Sedat/0000-0002-0671-8529
dc.authoridSAHINTURK, VAROL/0000-0003-2317-3644
dc.authorwosidkar, fatih/AAN-4285-2021
dc.authorwosidkar, fatih/AAI-4540-2021
dc.authorwosidhacioglu, ceyhan/ABB-5317-2020
dc.authorwosidKacar, Sedat/I-2544-2019
dc.authorwosidSAHINTURK, VAROL/V-5195-2017
dc.contributor.authorHacioglu, Ceyhan
dc.contributor.authorKar, Fatih
dc.contributor.authorKacar, Sedat
dc.contributor.authorSahinturk, Varol
dc.contributor.authorKanbak, Gungor
dc.date.accessioned2021-12-01T18:48:46Z
dc.date.available2021-12-01T18:48:46Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractBoric acid is known to regulate the proliferation of cancer cells. Prostate cancer is among the types of cancer with high mortality in men. There are a few numbers of studies investigating the effects of boric acid on prostate cancer cells. The objective of the present study was to assess the effects of boric acid at concentrations higher than that can be achieved in blood by dietary intake on DU-145 human prostate cancer cells for 24 h. Firstly, we determined the cytotoxic activity of boric acid (0 to 12.5 mM) on DU-145 human prostate cancer cells by using 3-(4, 5-dimethylthiazol, 2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) and defined the IC50 concentration of boric acid. Then, by employing the doses found in MTT, the levels of antioxidant-oxidant molecules and apoptotic proteins were measured and morphological changes were evaluated. We have concluded that boric acid caused oxidative stress, inhibition of cell growth, apoptosis, and morphological alterations in a concentration-dependent manner in DU-145 cells. Furthermore, treatments with increasing boric acid concentrations decreased the antioxidant levels in cells. We actually revealed that boric acid, known as an antioxidant, may prevent cell proliferation by acting as an oxidant in certain doses. Although the high IC50 concentration of boric acid is perceived to be negative, we think it provides important background for subsequent studies.en_US
dc.identifier.doi10.1007/s12011-019-01739-x
dc.identifier.endpage409en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid31066018en_US
dc.identifier.scopus2-s2.0-85065472117en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage400en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-019-01739-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10602
dc.identifier.volume193en_US
dc.identifier.wosWOS:000512037400012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBoric aciden_US
dc.subjectDU-145 prostate cellen_US
dc.subjectOxidative stressen_US
dc.subjectApoptosisen_US
dc.subjectBaxen_US
dc.subjectDAPIen_US
dc.subjectHematoxylin-eosinen_US
dc.subjectInhibits Human Prostateen_US
dc.subjectPhenylboronic Aciden_US
dc.subjectBoron-Compoundsen_US
dc.subjectDietary Boronen_US
dc.subjectLung-Canceren_US
dc.subjectProteinsen_US
dc.subjectDeprivationen_US
dc.subjectExpressionen_US
dc.subjectTherapyen_US
dc.subjectReleaseen_US
dc.titleHigh Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Lineen_US
dc.typeArticleen_US

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