Synthesis, Spectral Characterizations and Antimicrobial Activity of 5-methoxy-2-(5-H/Me/F/Cl/Br/NO2/OMe-1H-benzimidazol-2-yl)-phenols and Their ZnCl2 Complexes

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dc.contributor.authorTavman, Aydın
dc.contributor.authorGürbüz, Demet
dc.contributor.authorÖksüz, Şükrü
dc.contributor.authorÇınarlı, Adem
dc.date.accessioned2020-04-30T23:32:30Z
dc.date.available2020-04-30T23:32:30Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCINARLI, ADEM/0000-0003-3168-8058; GURBUZ, DEMET/0000-0002-4679-7890en_US
dc.descriptionWOS: 000437121400013en_US
dc.description.abstract5-Methoxy-2-(5-H/Me/F/Cl/Br/NO2/OMe-1H-benzimidazol-2-yl)-phenols (HL1- HL7) and their complexes with ZnCl2 were synthesized. The structures of the ligands and the complexes were confirmed on the basis of elemental analysis and FT-IR, FT Raman, H-1-NMR and fluorescence spectroscopic techniques. In addition, molar conductivity was carried out for the ZnCl2 complexes. In the complexes, the ligands acted as bidentate, via the imine nitrogen and the phenolate oxygen atoms. Fluorescence characteristics of the compounds were observed in ethanol: The ligands fluoresce as dual or triple whereas the complexes give dual or single fluorescence and most of them blue shifted. In addition, fluorescence spectra of HL1 were investigated in various solvents. The compounds were screened for in vitro antimicrobial activities against S. aureus, E. faecalis, E. coli I, E. coli II, K pneumoniae, P. aeruginosa, A. baumannii and for antifungal activity against C. albicans. The compounds HL4, [Zn(HL4)(2)Cl-2]center dot 2H(2)O, HL5, HL6 and [Zn(HL6)(2)O-2]center dot 4H(2)O exhibit antibacterial and antifungal activity against S. aureus, E. faecalis and C. albicans. It is observed that the Cl, Br and NO2 groups increase the antimicrobial activity toward S. aureus, E. faecalis and C. albicans. These results can be considered as selective activity.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul UniversityIstanbul Universityen_US
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Istanbul University.en_US
dc.identifier.endpage341en_US
dc.identifier.issn2351-812X
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage328en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4738
dc.identifier.volume6en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Mohammed Premier Oujdaen_US
dc.relation.ispartofMoroccan Journal Of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazoleen_US
dc.subjectMethoxyphenolen_US
dc.subjectZinc(II) Complexesen_US
dc.subjectFluorescenceen_US
dc.subjectAntimicrobial activityen_US
dc.titleSynthesis, Spectral Characterizations and Antimicrobial Activity of 5-methoxy-2-(5-H/Me/F/Cl/Br/NO2/OMe-1H-benzimidazol-2-yl)-phenols and Their ZnCl2 Complexesen_US
dc.typeArticleen_US

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