Comparison of the effectiveness and safety of vaginal and sublingual low-dose misoprostol versus vaginal dinoprostone for labor ınduction: A retrospective cohort study

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dc.contributor.authorEminov, Elmin
dc.contributor.authorEminov, Ayse
dc.date.accessioned2026-07-01T11:39:37Z
dc.date.available2026-07-01T11:39:37Z
dc.date.issued2025
dc.departmentDüzce Üniversitesi
dc.description.abstractBackground Labor induction is one of the most common obstetric interventions, yet the optimal pharmacological agent and route of administration remain subjects of ongoing debate. Prostaglandin analogs such as misoprostol and dinoprostone are widely used for cervical ripening and induction; however, evidence comparing their effectiveness and safety across different routes is still limited.Aim The primary purpose of the study is to evaluate the efficacy and safety of vaginal and sublingual misoprostol and vaginal dinoprostone pessary in labor induction.Materials and Methods Patients were divided into three groups based on the labor induction methods used. The first group included patients who received 25 mu g vaginal misoprostol for labor induction, the second group included patients who received 25 mu g sublingual misoprostol, and the third group included patients who received vaginal dinoprostone pessary. The primary outcome of the study was to evaluate vaginal delivery rates and time from induction to delivery of the fetus. The secondary outcomes of the study were to evaluate cesarean delivery rates, indications for cesarean delivery, first- and fifth-minute Apgar scores, birth weight, gender, amniotic fluid meconium contamination, and admission rates to the neonatal intensive care unit (NICU). The study data were collected from the hospital's automation system and archives. All patients' demographic and obstetric characteristics and maternal and fetal outcomes were recorded in a spreadsheet document (Microsoft Excel (TM)), and statistical analyses were performed using the SPSS 28.0 program.Results Vaginal delivery rates were higher in the group where vaginal (86,5%) and sublingual misoprostol (85,3%) were applied, and cesarean delivery rates were higher in the group where vaginal dinoprostone pessary (31,6%) was applied (p = 0.000). When the groups were compared according to the duration of labor, no difference was found in the vaginal (523.86 +/- 405,92) and sublingual misoprostol (560.15 +/- 438,00) groups, while the duration of labor was significantly higher in the dinoprostone pessary group (857.37 +/- 558,36) (p = 0.000). Hyperstimulation (6.8%) (p = 0.007) and admission rates to the neonatal intensive care unit (9.1%) (p = 0.004) were higher in the dinoprostone group, and this difference was statistically significant.Conclusion According to the results of the study, low-dose vaginal or sublingual misoprostol was found to be more effective and safer than vaginal dinoprostone pessary in labor induction.
dc.identifier.doi10.1371/journal.pone.0336025
dc.identifier.issn1932-6203
dc.identifier.issue10
dc.identifier.orcid0000-0003-1587-1821
dc.identifier.pmid41171935
dc.identifier.scopus2-s2.0-105020645906
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0336025
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23368
dc.identifier.volume20
dc.identifier.wosWOS:001606904300007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260623
dc.subject[Keyword Not Available]
dc.titleComparison of the effectiveness and safety of vaginal and sublingual low-dose misoprostol versus vaginal dinoprostone for labor ınduction: A retrospective cohort study
dc.typeArticle

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