Progesterone Treatment After Experimental Spinal Cord Injury

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dc.contributor.authorÇalıkoğlu, Çağatay
dc.contributor.authorÖzşahin, Mustafa
dc.contributor.authorUslu, Mustafa
dc.contributor.authorAkgül, Mehmet H.
dc.contributor.authorErdem, Havva
dc.date.accessioned2020-04-30T23:21:44Z
dc.date.available2020-04-30T23:21:44Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000327090200002en_US
dc.description.abstractObjective/Background:A growing list of studies gives evidence for the efficacy of progesterone in the nervous systems. Neuroprotective effects of progesterone are well documented for the injured brain models in the literature. However, the effects of progesterone on spinal cord injury (SCI) should be investigated.Methods:Twenty adult male Wistar-Albino rats were included in the study. The rats were randomly allocated into two groups (Control and Progesterone). Progesterone was administered in five days at a dose of 4 mg/kg via intraperitoneal route. Each group underwent motor examination in sixth weeks using Basso, Beattie and Bresnehan (BBB) locomotor test.Results:The score mean values of the control and study groups receiving progesterone treatment after six weeks were 11.40.427 and 14.1 +/- 0.526, respectively (P<0.05). While the improvement process showed a nearly parallel course between the two groups until the end of the third week, the progesterone treated group exhibited a significant difference in BBB scores relative to the control starting from the fourth week (P<0.05). On the examined histological sections, it was determined that progesterone had clear neuroprotective effects.Conclusions:The results supported the fact that progesterone could be a potentially effective therapeutic strategy to treat SCI.en_US
dc.identifier.doi10.1097/WNQ.0b013e318275ddb8en_US
dc.identifier.endpage234en_US
dc.identifier.issn1050-6438
dc.identifier.issn1534-4916
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage230en_US
dc.identifier.urihttps://doi.org/10.1097/WNQ.0b013e318275ddb8
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4242
dc.identifier.volume23en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNeurosurgery Quarterlyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectprogesteroneen_US
dc.subjectneurosteroiden_US
dc.subjectneuroprotectionen_US
dc.subjectspinal cord injuryen_US
dc.subjectneurotraumaen_US
dc.titleProgesterone Treatment After Experimental Spinal Cord Injuryen_US
dc.typeArticleen_US

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