FDG and FDG-labelled leucocyte PET/CT in the imaging of prosthetic joint infection

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dc.contributor.authorAksoy, Sabire Yılmaz
dc.contributor.authorAsa, Sertaç
dc.contributor.authorÖzhan, Meftune
dc.contributor.authorOcak, Meltem
dc.contributor.authorSağer, M. Sait
dc.contributor.authorErkan, Melih Engin
dc.contributor.authorKanmaz, Bedii
dc.date.accessioned2020-05-01T12:10:03Z
dc.date.available2020-05-01T12:10:03Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionSonmezoglu, Kerim/0000-0003-1215-5184; Kabasakal, Levent/0000-0002-4050-1972; ocak, meltem/0000-0001-9214-3938en_US
dc.descriptionWOS: 000330966600018en_US
dc.descriptionPubMed: 24196917en_US
dc.description.abstractPurpose The demand for arthroplasty is rapidly growing as a result of the ageing of the population. Although complications such as heterotrophic ossification, fracture and dislocation are relatively rare, differentiating aseptic loosening, the most common complication of arthroplasty from infection, is a major challenge for clinicians. Radionuclide imaging is currently the imaging modality of choice since it is not affected by orthopaedic hardware. Whereas FDG PET/CT imaging has been widely used in periprosthetic infection, it cannot discriminate aseptic from septic inflammation. In this study we aimed to evaluate the role of FDG PET/CT and FDG-labelled leucocyte PET/CT in the diagnosis of periprosthetic infection. Methods Of 54 patients with painful joint arthroplasty who were imaged by FDG PET/CT for diagnosis of periprosthetic infection examined, 46 (36 women, 10 men; mean age 61.04 +/- 12.2 years, range 32 - 89 years) with 54 painful joint prostheses (19 hip, 35 knee) with grade 2 (above liver uptake) FDG accumulation on FDG PET/CT were included in the study and these 46 patients also underwent FDG-labelled leucocyte PET/CT. Final diagnoses were made by histopathological-microbiological culture or clinical follow-up. Results The final diagnosis showed infection in 15 (28 %) and aseptic loosening in 39 (72 %) of the 54 prostheses. FDG PET/CT was found to have a positive predictive value of 28 % (15/54). Since patients with no FDG uptake on FDG PET/CT were excluded from the study, the sensitivity, specificity, negative predictive value and accuracy could not be calculated. The sensitivity, specificity, and positive and negative predictive values of FDG-labelled leucocyte PET/CT were 93.3 % (14/15), 97.4 % (38/39), 93.3 % and 97.4 %, respectively. Conclusion Since FDG is not specific to infection, the specificity of FDG PET/CT was very low. FDG-labelled leucocyte PET/CT with its high specificity may be a useful method and better than labelled leucocyte scintigraphy in periprosthetic infection imaging.en_US
dc.identifier.doi10.1007/s00259-013-2597-2en_US
dc.identifier.endpage564en_US
dc.identifier.issn1619-7070
dc.identifier.issn1619-7089
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage556en_US
dc.identifier.urihttps://doi.org/10.1007/s00259-013-2597-2
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5956
dc.identifier.volume41en_US
dc.identifier.wosWOS:000330966600018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Nuclear Medicine And Molecular Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFDG-labelled leucocytesen_US
dc.subjectProsthetic joint infectionen_US
dc.subjectPET/CTen_US
dc.titleFDG and FDG-labelled leucocyte PET/CT in the imaging of prosthetic joint infectionen_US
dc.typeArticleen_US

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