Can in vitro maturation overcome cycles with repeated oocyte maturation arrest? A classification system for maturation arrest and a cohort study

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dc.contributor.authorHatirnaz, Safak
dc.contributor.authorBasbug, Alper
dc.contributor.authorHatirnaz, Ebru
dc.contributor.authorTannus, Samer
dc.contributor.authorHatirnaz, Kaan
dc.contributor.authorBakay, Kadir
dc.contributor.authorDahan, Michael H.
dc.date.accessioned2021-12-01T18:50:55Z
dc.date.available2021-12-01T18:50:55Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractObjective To investigate the role of gonadotropin-stimulated and human chorionic gonadotropin (hCG) -primed in vitro oocyte maturation (IVM) in cases of repeated in vitro fertilization (IVF) failure due to various forms of oocyte maturation arrest (OMA). Methods Retrospective cohort study. Results In all, 63 women with IVF failure due to OMA were evaluated in this study. According to the Hatirnaz & Dahan classification, 11 (17.5%) women were OMA type 1, 22 (34.9%) were OMA type 2, 0 were OMA type 3, 11 (17.5%) were OMA type 4, and 19 women were OMA type 5 (30.1%). Fewer oocytes were retrieved in the IVM than in the IVF cycles. No embryos were produced from oocytes collected in the IVM cycles of women with OMA types 1, 2, and 4. In the OMA type 5 group, 9 (47.4%) day 2 embryos and 6 (31.6%) day 3 embryos were obtained. The difference between the groups was statistically significant (P = 0.001, P = 0.002, respectively). Single day 3 embryo transfer was performed for the six patients with OMA type 5 but no clinical pregnancies occurred. Conclusions Follicle-stimulating hormone-stimulated and hCG-primed IVM does not improve oocyte maturation, developmental potential, or pregnancy rates of women with OMA. Future studies directed to re-establishing normal cytoskeletal architecture and machinery, and resumption of meiosis may be beneficial for obtaining mature oocytes.en_US
dc.identifier.doi10.1002/ijgo.13490
dc.identifier.endpage502en_US
dc.identifier.issn0020-7292
dc.identifier.issn1879-3479
dc.identifier.issue3en_US
dc.identifier.pmid33216990en_US
dc.identifier.scopus2-s2.0-85097807863en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage496en_US
dc.identifier.urihttps://doi.org/10.1002/ijgo.13490
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10943
dc.identifier.volume153en_US
dc.identifier.wosWOS:000600569100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Gynecology & Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectembryonic developmenten_US
dc.subjectin vitro fertilizationen_US
dc.subjectin vitro maturationen_US
dc.subjectoocyte maturation arresten_US
dc.subjectpregnancyen_US
dc.subjectMeiotic Arresten_US
dc.titleCan in vitro maturation overcome cycles with repeated oocyte maturation arrest? A classification system for maturation arrest and a cohort studyen_US
dc.typeArticleen_US

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