Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta (1-42)

Basit Öğe Kaydı
dc.authoridKAR, Ezgi/0000-0003-2134-4067
dc.authoridkar, fatih/0000-0001-8356-9806
dc.authoridHacioglu, Ceyhan/0000-0002-0993-6118
dc.authorwosidKAR, Ezgi/AAR-1992-2020
dc.authorwosidkar, fatih/AAI-4540-2021
dc.authorwosidKara, Yakup/AAW-8736-2020
dc.authorwosidkar, fatih/AAN-4285-2021
dc.contributor.authorHacioglu, Ceyhan
dc.contributor.authorKar, Fatih
dc.contributor.authorKar, Ezgi
dc.contributor.authorKara, Yakup
dc.contributor.authorKanbak, Gungor
dc.date.accessioned2021-12-01T18:49:33Z
dc.date.available2021-12-01T18:49:33Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractSynaptosomes are used as an ex vivo model in the investigation of neuronal transmission and neurodegenerative processes. In this study, we aimed to determine the protective effects of boric acid (BA) and curcumin, which have antioxidant and anti-inflammatory properties, on A beta 1-42 induced neurodegenerative damage. Synaptosomes obtained from the rat cerebral cortex were divided into five groups: control, 10 mu M A beta 1-42, 10 mu M A beta 1-42 + 25 mM BA, 10 mu M A beta 1-42 + 10 mu M curcumin, and 10 mu M A beta 1-42 + 25 mM BA+10 mu M curcumin. Synaptosomes treated with A beta 1-42 caused a significant decline in synaptophysin levels and increase in malondialdehyde (MDA) levels, acetylcholinesterase (AChE) activities, DNA fragmentation values, and nitric oxide (NO) levels compared with the control group (P < 0.01). Synaptosomes treated with BA showed a significant reduction in MDA and NO levels against A beta 1-42 exposure (P < 0.01). In addition, curcumin treatment has been found to cause a significant reduction in AChE activities and MDA levels in synaptosomes (P < 0.05). Co-administration of BA and curcumin on synaptosomes exposed to A beta 1-42 resulted in a significant decrease in DNA fragmentation values, MDA levels, and AChE activities. Curcumin and BA + curcumin combination showed an enhancement in synaptophysin levels of A beta 1-42-induced synaptosomes (P < 0.01). The results showed that BA and curcumin had protective effects on rat brain synaptosomes against A beta 1-42 exposure. BA and curcumin treatment can have abilities to prevent the alterations of the cholinergic system and inhibit oxidative stress in the cerebral cortex synapses of A beta 1-42 exposed.en_US
dc.identifier.doi10.1007/s12011-020-02511-2
dc.identifier.endpage3800en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85096556157en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3793en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-020-02511-2
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10741
dc.identifier.volume199en_US
dc.identifier.wosWOS:000592576200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer&#8217en_US
dc.subjects diseasesen_US
dc.subjectAmyloid betaen_US
dc.subjectBoric aciden_US
dc.subjectCurcuminen_US
dc.subjectNeurodegenerationen_US
dc.subjectOxidative stressen_US
dc.subjectSynaptophysinen_US
dc.subjectSynaptosomeen_US
dc.subjectAlzheimers-Diseaseen_US
dc.subjectOxidative Stressen_US
dc.subjectDna-Damageen_US
dc.subjectPeptideen_US
dc.subjectSynaptophysinen_US
dc.subjectTauen_US
dc.subjectPathogenesisen_US
dc.subjectExpressionen_US
dc.subjectHypothesisen_US
dc.subjectPreventionen_US
dc.titleEffects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta (1-42)en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
10741.pdf
Boyut:
578.99 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu