The Protective Effect of Resveratrol on Cisplatin Induced Damage in Rat Liver

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dc.contributor.authorKara, Özlem
dc.contributor.authorKilitci, Asuman
dc.date.accessioned2023-07-26T11:58:33Z
dc.date.available2023-07-26T11:58:33Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractAim: One of the underlying causes of cisplatin-induced hepatotoxicity is oxidative stress. We assessed the effect of an antioxidant, resveratrol, on cisplatin-induced damage in the rat liver. Methods: The project-starting date was designed as 01.10.2020 and the project-ending date was planned as 01.04.2021. Three groups were created with 30 female Wistar-Albino rats: In group 1 (control group), 1 mL of 0.9% NaCl (saline) was administered intraperitoneally for 3 days. In group 2 (cisplatin group), 7.5 mg/kg intraperitoneal cisplatin was given for 3 days. In group 3 (cisplatin + resveratrol group), 7.5 mg/kg cisplatin and 10 mg/kg resveratrol were given via the intraperitoneal route. The livers were surgically extirpated in all the groups. In both blood and tissues, malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured. Also, toxicity markers such as hepatocyte damage (cellular changes), inflammation, hemorrhage, congestion, fibrosis, disorganization of the hepatic cords, and necrosis were assessed by examining the preparations prepared from hepatic tissue with light microscopy and immunohistochemistry. Results: Histopathological tissue damage was significantly higher in group 2 than in other groups (p 0.03). MDA levels were significantly higher and the activities of SOD and CAT were lower in group 2 than in the other groups (p=0.04 and p=0.01, respectively). Conclusion: According to our short-term findings, resveratrol might be an effective molecule for preventing the harmful effects of cisplatin in the rat liver.en_US
dc.identifier.doi10.4274/haseki.galenos.2022.8098
dc.identifier.endpage396en_US
dc.identifier.issn1302-0072
dc.identifier.issn2147-2688
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85139973275en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage392en_US
dc.identifier.trdizinid1132488en_US
dc.identifier.urihttps://doi.org/10.4274/haseki.galenos.2022.8098
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1132488
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13517
dc.identifier.volume60en_US
dc.identifier.wosWOS:000885959000015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKilitci, Asuman
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofHaseki Tip Bulteni-Medical Bulletin of Hasekien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectCisplatin; Resveratrol; Rat; Liver; Toxicityen_US
dc.subjectInduced Nephrotoxicity; Oxidative Stress; Hepatotoxicityen_US
dc.titleThe Protective Effect of Resveratrol on Cisplatin Induced Damage in Rat Liveren_US
dc.typeArticleen_US

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