Differentially Expressed Genes Associated with Body Size Changes and Transposable Element Insertions between Caenorhabditis elegans and Its Sister Species, Caenorhabditis inopinata

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dc.authoridDAYI, Mehmet/0000-0002-5367-918Xen_US
dc.authoridMakino, Takashi/0000-0003-4600-9353en_US
dc.authoridKawata, Masakado/0000-0001-8716-5438en_US
dc.authorscopusid58248337100en_US
dc.authorscopusid58248337200en_US
dc.authorscopusid50162446200en_US
dc.authorscopusid53984165500en_US
dc.authorscopusid40961282400en_US
dc.authorscopusid7402874517en_US
dc.authorscopusid8638527500en_US
dc.authorwosidDAYI, Mehmet/GQP-8056-2022en_US
dc.contributor.authorKawahara, Kazuma
dc.contributor.authorInada, Taruho
dc.contributor.authorTanaka, Ryusei
dc.contributor.authorDayi, Mehmet
dc.contributor.authorMakino, Takashi
dc.contributor.authorMaruyama, Shinichiro
dc.contributor.authorKikuchi, Taisei
dc.date.accessioned2024-08-23T16:04:20Z
dc.date.available2024-08-23T16:04:20Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractWhy the recently discovered nematode Caenorhabditis inopinata differs so greatly from its sibling species Caenorhabditis elegans remains unknown. A previous study showed that C. inopinata has more transposable elements (TEs), sequences that replicate and move autonomously throughout the genome, potentially altering the expression of neighboring genes. In this study, we focused on how the body size of this species has evolved and whether TEs could affect the expression of genes related to species-specific traits such as body size. First, we compared gene expression levels between C. inopinata and C. elegans in the L4 larval and young adult stages-when growth rates differ most prominently between these species-to identify candidate genes contributing to their differences. The results showed that the expression levels of collagen genes were consistently higher in C. inopinata than in C. elegans and that some genes related to cell size were differentially expressed between the species. Then, we examined whether genes with TE insertions are differentially expressed between species. Indeed, the genes featuring C. inopinata-specific TE insertions had higher expression levels in C. inopinata than in C. elegans. These upregulated genes included those related to body size, suggesting that these genes could be candidates for artificial TE insertion to examine the role of TEs in the body size evolution of C. inopinata.en_US
dc.description.sponsorshipJapan Society for the Promotion of Science (JSPS), KAKENHI [18K1935]; Japan Science and Technology Agency (JST); CREST [JPMJCR18S7]en_US
dc.description.sponsorshipThis work was supported by Japan Society for the Promotion of Science (JSPS), KAKENHI (Grant Number 18K1935 to M.K.), Japan Science and Technology Agency (JST), and CREST (Grant Number JPMJCR18S7 to A.S.).en_US
dc.identifier.doi10.1093/gbe/evad063
dc.identifier.issn1759-6653
dc.identifier.issue4en_US
dc.identifier.pmid37071793en_US
dc.identifier.scopus2-s2.0-85159242923en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1093/gbe/evad063
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14171
dc.identifier.volume15en_US
dc.identifier.wosWOS:000978089000003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofGenome Biology And Evolutionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmajor evolutionary changeen_US
dc.subjectgene expressionen_US
dc.subjectCaenorhabditis inopinataen_US
dc.subjectnematodeen_US
dc.subjectTgf-Betaen_US
dc.subjectCell-Sizeen_US
dc.subjectRna Interferenceen_US
dc.subjectCollagen Genesen_US
dc.subjectEvolutionen_US
dc.subjectGrowthen_US
dc.subjectPathwayen_US
dc.subjectInsulin/Igfen_US
dc.subjectMetabolismen_US
dc.subjectOrganen_US
dc.titleDifferentially Expressed Genes Associated with Body Size Changes and Transposable Element Insertions between Caenorhabditis elegans and Its Sister Species, Caenorhabditis inopinataen_US
dc.typeArticleen_US

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