Electro-oxidation of cytostatic drugs: Experimental and theoretical identification of by-products and evaluation of ecotoxicological effects

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dc.contributor.authorBarışçı, Sibel
dc.contributor.authorTürkay, Özge
dc.contributor.authorUlusoy, Ebru
dc.contributor.authorŞeker, Mine Gül
dc.contributor.authorYüksel, Ebubekir
dc.contributor.authorDimoglo, Anatoli
dc.date.accessioned2020-05-01T12:11:52Z
dc.date.available2020-05-01T12:11:52Z
dc.date.issued2018
dc.departmentDÜ, Orman Fakültesi, Orman Endüstrisi Mühendisliği Bölümüen_US
dc.descriptionBarisci, Sibel/0000-0003-4229-0408; Dinc, Ozge/0000-0002-3029-7840en_US
dc.descriptionWOS: 000418533400181en_US
dc.description.abstractMethotrexate (MTX) and Capecitabine (CPC) as mostly used cytostatic drugs were degraded by electro-oxidation process in this study. Ti/IrO2-RuO2 electrode was used to provide anodic oxidation. The effect of change of current density, initial pH of the solution and supporting electrolyte concentration on electro-oxidation of cytostatic drugs was evaluated. Current density of 30 mA/cm(2), neutral pH and supporting electrolyte concentration of 200 mg L-1 were determined as optimum operational parameters. After oxidation process, the transformation by-products of cytostatic drugs were identified by LC-MS-MS analysis. Density functional theory (DFT) modelling was performed and the calculations were given in harmony with analytic results. In addition, toxicity evaluation on the electro-oxidation was assessed due to the possible toxic effect of the metabolites after treatment process. Indeed, the transformation by-products of MTX showed toxic effects after treatment, however; the metabolites CPC did not cause toxicity although lower removal efficiency.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Y606]en_US
dc.description.sponsorshipThe authors thank The Scientific and Technological Research Council of Turkey (TUBITAK) for their financial support [Project number: 114Y606].en_US
dc.identifier.doi10.1016/j.cej.2017.11.105en_US
dc.identifier.endpage1827en_US
dc.identifier.issn1385-8947
dc.identifier.issn1873-3212
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1820en_US
dc.identifier.urihttps://doi.org/10.1016/j.cej.2017.11.105
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6218
dc.identifier.volume334en_US
dc.identifier.wosWOS:000418533400181en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofChemical Engineering Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCapecitabineen_US
dc.subjectCytostaticen_US
dc.subjectElectro-oxidationen_US
dc.subjectMethotrexateen_US
dc.subjectToxicityen_US
dc.subjectDFT modellingen_US
dc.titleElectro-oxidation of cytostatic drugs: Experimental and theoretical identification of by-products and evaluation of ecotoxicological effectsen_US
dc.typeArticleen_US

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