Comparison of Vitex Agnus castus with meloxicam and placebo in treatment of patients with cyclical mastalgia

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dc.contributor.authorAydın, İbrahim
dc.contributor.authorBaltacı, Davut
dc.contributor.authorTürkyılmaz, Serdar
dc.contributor.authorÖncü, Mustafa
dc.date.accessioned2020-04-30T13:32:15Z
dc.date.available2020-04-30T13:32:15Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Mastalgia is classified as cyclic and non-cyclic. Cyclical one constitutes approximately 60-70% of mastalgia. It is seen between 2 to 3 decades of age, and it usually responds to treatment. Objectives: To compare efficacy of vitex agnus castus (VAC) preparation with meloxicam and placebo in treatment of mastalgia. Methods: The study was designed as prospective and placebo-controlled clinical trial. Three groups were constituted. Before grouping, prolactin level was tested for every patient. The group1 enrolled the patients with cyclical mastalgia and high level prolactin. VAC was administered to patients from study group1. The second group enrolled the patients with cyclical mastalgia along with normal prolactin level, and to which meloxicam was given. Third group was placebo group, and placebo was applied. Before treatment, VAS (Visual analogue scale) scoring was applied to every patient. Prolactin level was tested for patients from group 1. After 3 months of study, VAS scoring was applied to every patient, but only prolactin levels were re- evaluated in patients from group1. Results: 95 patients were analyzed; enrolling women aged 19 to 54 years. Intensity of mastalgia diminished in VAC group 1, 2 more than in placebo group (p<0.0001). In addition to VAS scoring, prolactin level in group 1 after treatment was significantly reduced, comparing with before treatment (p<0.0001). In conclusion, we found that VAC preparation was effective in the treatment of mastalgia and hyperprolactinemia, with good tolerability. © 2011 Düzce Medical Journal.en_US
dc.identifier.endpage5en_US
dc.identifier.issn1307671X
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/185
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMastalgia; Prolactin; Vitex agnus castusen_US
dc.titleComparison of Vitex Agnus castus with meloxicam and placebo in treatment of patients with cyclical mastalgiaen_US
dc.title.alternativeSiklik mastaljili hastaların tedavisinde vitex agnus castus preperatının meloksikam ve plasebo i?le karşılaştırılmasıen_US
dc.typeArticleen_US

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