Evaluation of renal elasticity by shear wave elastography in children with Familial Mediterranean Fever

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dc.authoridGokce, Ayse/0000-0002-2321-8630
dc.authoridSav, Nadide Melike/0000-0003-1520-6426
dc.authoridAltinsoy, Hasan Baki/0000-0003-0934-3600
dc.authoridTuren, Betul/0000-0001-7011-0246
dc.contributor.authorSav, Nadide Melike
dc.contributor.authorAltinsoy, Hasan Baki
dc.contributor.authorTuren, Betul
dc.contributor.authorGokce, Ayse
dc.date.accessioned2025-10-11T20:48:46Z
dc.date.available2025-10-11T20:48:46Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground Familial Mediterranean Fever (FMF) is a genetic disorder that can cause kidney damage. Shear wave elastography (SWE), a non-invasive method, was used to evaluate the decrease in renal tissue elasticity as a predictive parameter for amyloidosis. This study aimed to examine the changes in renal elasticity in patients with FMF using the renal SWE measurement method. Methods The present study included 50 pediatric patients diagnosed with FMF. The median SWE values of both kidneys were compared between the groups. Acute phase reactants were also evaluated. Results The SWE measurements (for the left kidney p = 0.007, for the right kidney p = 0.06) and proteinuria levels (p < 0.001) of the patient group were found to be higher than those of the control group. No correlation was observed between the disease activity score and the SWE measurements. Erythrocyte sedimentation rate (p < 0.001), C-reactive protein (p < 0.001) and urine protein/creatinine ratio (p < 0.001) were significantly higher in the remission period compared to the control group, whereas estimated glomerular filtration rate was found to be low in the patient group (p < 0.001), which was considered as an indicator that subclinical inflammation continued in the course of the disease. Conclusions The acute phase reactants were elevated in patients with FMF even in the remission period which indicates that the disease is constantly active and have the potential to cause damage in all organs and tissues. It is thought that this subclinical inflammation may also contribute to increased tissue stiffness, which may serve as a predictor for the development of amyloidosis.en_US
dc.identifier.doi10.1007/s00467-024-06637-6
dc.identifier.endpage1709en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue5en_US
dc.identifier.pmid39779509en_US
dc.identifier.scopus2-s2.0-85217171814en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1701en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-024-06637-6
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22094
dc.identifier.volume40en_US
dc.identifier.wosWOS:001393044800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectChildrenen_US
dc.subjectFamilial mediterranean feveren_US
dc.subjectKidneyen_US
dc.subjectShear wave elastographyen_US
dc.titleEvaluation of renal elasticity by shear wave elastography in children with Familial Mediterranean Feveren_US
dc.typeArticleen_US

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