Modeling the Cluster Size Distribution of Vascular Endothelial Growth Factor (VEGF) Receptors

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dc.contributor.authorGüven, Emine
dc.contributor.authorWester, Michael J.
dc.contributor.authorEdwards, Jeremy S.
dc.contributor.authorHalasz, Adam M.
dc.date.accessioned2023-07-26T11:54:23Z
dc.date.available2023-07-26T11:54:23Z
dc.date.issued2022
dc.departmentDÜ, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractWe previously developed a method of defining receptor clusters in the membrane based on mutual distance and applied it to a set of transmission microscopy images of vascular endothelial growth factor receptors. An optimal length parameter was identified, resulting in cluster identification and a procedure that assigned a geometric shape to each cluster. We showed that the observed particle distribution results were consistent with the random placement of receptors within the clusters and, to a lesser extent, the random placement of the clusters on the cell membrane. Here. we develop and validate a stochastic model of clustering, based on a hypothesis of preexisting domains that have a high affinity for receptors. The proximate objective is to clarify the mechanism behind cluster formation and to estimate the effect on signaling. Receptor-enriched domains may significantly impact signaling pathways that rely on ligand-induced dimerization of receptors. We define a simple statistical model, based on the preexisting domain hypothesis, to predict the probability distribution of cluster sizes. The process yielded sets of parameter values that can readily be used in dynamical calculations as the estimates of the quantitative characteristics of the clustering domains.en_US
dc.identifier.doi10.1177/11779322221085078
dc.identifier.issn1177-9322
dc.identifier.pmid35356495en_US
dc.identifier.scopus2-s2.0-85127253126en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1177/11779322221085078
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12815
dc.identifier.volume16en_US
dc.identifier.wosWOS:000775642000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGüven, Emine
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofBioinformatics and Biology Insightsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectCell Signaling; Receptors; Receptor Clustering; Vegf; Membrane Organizationen_US
dc.subjectMembrane; Tracking; Imageen_US
dc.titleModeling the Cluster Size Distribution of Vascular Endothelial Growth Factor (VEGF) Receptorsen_US
dc.typeArticleen_US

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